Nipah virus disease is emerging disease caused by highly pathogenic paramyxoviruses. It is spread by contaminated food with secretions of infected bats to animals and human or directly between infected to healthy one. It causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. Virus has ability to infect multiple organ systems, with a predominant neurological or respiratory tropism. Initial signs and symptoms of infection are nonspecific, hence early diagnosis is difficult. To overcome this awful situation efforts to prevent transmission and development of new effective drugs should first focused.