Agricultural Reviews

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Agricultural Reviews, volume 45 issue 2 (june 2024) : 239-248

Signaling for Abiotic Stress Tolerance in Plants: A Review

Mandeep Singh1,*, Usha Nara1, Antul Kumar2, Chandan Jaswal1
1Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, Punjab, India.
2Department of Botany, Punjab Agricultural University, Ludhiana-141 004, Punjab, India.
Cite article:- Singh Mandeep, Nara Usha, Kumar Antul, Jaswal Chandan (2024). Signaling for Abiotic Stress Tolerance in Plants: A Review . Agricultural Reviews. 45(2): 239-248. doi: 10.18805/ag.R-2306.
Plants copiously rely on intense sensitivity recognition and acclimation mechanisms to cope against various environmental perturbations. Abiotic stresses such as water availability (drought or flooding), salinity, nutrient stress and metal stress aregrievous threatto the global agriculture as they hinder the crop plant to attain its whole genetic potential resulting in the notable yield loss. Signal transduction networks validate the plants in stress signal perception accompanied by transduction than finally inception of the response. Stress signal transduction and its perception is hugely decisive step to conquer these environmental obstacles for the better growth and survival of the crop plant. This review emphasizes on various pathways namely hormone signaling and their cross talk, ROS signaling, ABA signaling, Ion homeostasis, MAPK pathways, SOS signaling and transcriptional factors (TFs). Peculiarly, in future recent biotechnological innovations will help in understanding the gene function and ingress to whole genome sequences provide new guidance for crop refinement.
ABA: Abscisic acid; CDPK: Calcium-dependent protein Kinase; JA: Jasmonic acid; MAPK: Mitogen-activated protein kinase; ROS: Reactive oxygen species; SOS: Salt overly sensitive; TFs: Transcription factors.
Abiotic stress in crop plants acts as great yield-restricting aspect (Canter, 2018; Zorb et al., 2019). Plants already flourishing in adverse conditions can cope up from the abiotic and biotic stresses by managing their tone to environment (Bailey-Serres et al., 2019; Hu et al., 2022). Plants reproduce and grow in a vigorous environment able to see instantaneous transformation in conditions like temperature, intensity of light or interaction with some biotic factors. Due to sessile nature of the plants, the devastating effect of climate results in the alleviation in the growth of plant (Zhu, 2016). Changing environment conditions include various type of abiotic stress namely, cold, heat, excess of salt, nutrient deficiency, or some noxious metals such as cadmium, arsenate and aluminium in the soil. Out of these abiotic stress, salt, drought and stress of temperature are the main factors which affect the agricultural productivity (Fedoroff et al., 2010; Vaughan et al., 2018; Waqas et al., 2017; Zafar et al., 2018; Singh et al., 2021a). Among abiotic stresses, drought and salinity has been reported to adversely affect >10% cultivable land leading to decrease incrop productivity up to 50% (Roychoudhury et al., 2013). Plants adapt various mechanisms to escape itself from various environmental injuries like biotic and abiotic stresses. In, escaping itself from stresses, stress signals perception and transduction of signals is an influential step for various responses to manage the stress whether there is a loss in yield as well as growth of the plant or for the survival of the plants (Bailey-Serres et al., 2019; Bobade et al., 2021).
Steps in signaling pathways
First step in signaling pathway is performed by the molecular sensors or receptors such as hormones, phytochromes, receptor-like kinases etc. Second step include the inception of secondary signaling molecules like ROS (reactive oxygen species), inositol phosphatase and abscisic acid. Third step in signaling pathways is through the secondary signaling molecule-mediated pathways including the intonation of Ca2+ level which cause the inception of protein phosphorylation cascades i.e., MAPK, MAPKK, MAPKKK, CDPK and SOS1, SOS2, SOS3 and transcription factors. General diagrammatic representation of the plant signal transduction pathway against abiotic stresses is shown in the Fig 1.

Fig 1: Schematic depiction of signal transduction pathways in response to various abiotic stresses such as temperature, drought and salinity.

Hormones and their cross talk in signaling
ABA already showed its potential role in abiotic stress via signaling but other hormones also play crucial role in the signaling of plants under various abiotic stressesis discussed below.

Jasmonic acid (JA) play an important role in abiotic stress signaling. Activation of jasmonate biosynthesis occur whenever there is a stress condition in the plant (Wasternack, 2007) and several genes are managed as a result of drought stress which take part in JA signaling (Huang et al., 2008). The change in JA level in the plants has also been reported (Choudhury et al., 2018). External application of methyl JA (MeJA) or Jasmonic acid leads to its conversion into bioactive form, namely iso-Jasmonyl-L-isoleucine (JA-Ile). This bioactive form of JA binds with the SCFCOI (coronatine insensitive) complex (Sheard et al., 2010). Munemasa et al., (2007) and Suhita et al., (2003; 2004) reported the crucial role of JA in the closing of stomata during drought stress. The anion channels (S-type) were activated by MeJA, with the help of which CDPK was activated leading to the stomatal closing during drought conditions (Munemasa et al., 2007).  Zhou et al. (2019) observed the production of jasmonic acid within seconds after wounding suggesting that endogenous hormonal regulation in the primary stress response.

Ethylene biosynthesis tends to increase during drought condition. Ethylene synthesis has been induced by increasing the synthesis of enzymes namely 1-Aminocyclopropane-1-carboxylic acid (ACC) oxidase and ACC synthase. Ethylene promotes plant senescence which helps the plant to decrease water losses during stress. Ethylene encourages adventitious root emergence helping the plant to grow via uptake of water during flooding conditions (Pistelli et al., 2012; Sairam et al., 2008). Inhibition of stomatal closing has been reported in Arabidopsis plants on exposer to external application of gaseous ethylene (Tanaka et al., 2005). Accumulation of ABA is negatively correlated with the ethylene production resulting in increased concentration of ABA (Abscisic acid) with the decrease in concentration of ethylene during the water stress conditions.

Brassinosteroid (BR) is a phytohormone having crucial role in the development and growth of the plant and acts as a defense against various abiotic and biotic stresses. BR in cooperation with ABA helps in the stomatal closing to reduce water losses via transpiration. Similar study in Vicia faba showed the stomatal closing by the epibrassinolide (EBL) application (Haubrick et al., 2006). External application of epibrassinolide (EBL) in Brassica napus and Arabidopsis thaliana, which are water scarcity resistance, causes resistance against drought (Fariduddin et al., 2014). BRs have interaction with other hormones to induce the tolerance against abiotic stresses. EB in plants decrease the synthesis of stress inducing hormones such as IAA (Indole acetic acid) and ABA but amount of cytokinin remained unchanged (Avalbaev et al., 2010).

Auxin, a phytohormone, helps in controlling the H+-ATPase movements in the guard cells. The invasion of K+ ion from the guard cells was promoted when there is an emission of H+ ion from the guard cells. Auxin when present in high amount, give rise to emission of K+ and inhibit the invasion resulting in closing of stomata but in low concentration of auxin, there is removal of K+ ion leads to stomatal opening (Daszkowska-Golec and Szarejko, 2013). ARFs (auxin response factors), Aux/IAAs (auxin/indole-acetic acid) and TPSs (TOPLESS proteins) are the three main transcription regulators which manage the auxin response genes transcription (Causier et al., 2012; Szemenyei et al., 2008; Zouine et al., 2014). Out of these three protein families, it is found that ARF family has its role in regulating the expression of genes. Many OsARFs are there in rice which play role in response to drought and salt stress (Jain and Khurana, 2009). Cytokinin (CKs) restrict the stomatal closing and assigned in relation with ABA (Tanaka et al., 2006) (Fig 2).

Fig 2: Signaling of plant growth regulators and their crosstalk.

ROS signaling
Abiotic stresses, such as cold, drought and salt stress induce the ROS (Reactive oxygen species) accumulation namely hydroxyl radicals, hydrogen peroxide and superoxide. ROS induce signals and act as harming agents which cause stress injury to the cells. It is reported that H2O2 production was induced by presence of ABA (Guan et al., 2000. The production of ROS may be induced through various mechanisms in response to heat and light stress (Pospisil, 2016). ROS may act as intermediate signals for closing of stomata (Zhang et al., 2001), Ca2+ channels activation in guard cells and biosynthesis of ABA (Zhao et al., 2001). ROS are produced continuously as products of metabolic pathways in the different sections of the cell. ROS are produced in the course of aerobic photosynthesis and photorespiration (Kotchoni et al., 2006). Increase in the ROS molecules can be seen in peroxisomes under various type of abiotic stresses (Mittler, 2002). It acts as intracellular signaling molecule and various investigations shows that transgenic plants having high rate of ROS generation and high ROS-scavenging capacity indicate much tolerance against stress (Hasegawa et al., 2000; Kocsy et al., 2001). Possessingthe property of most energetic compound and highreactivity ROS molecules are suitable in activation of plant stress signaling (Foyer and Noctor, 2005). A study on yeast and animal suggests that MAPK pathway which was activated by histidine kinase also play a role in mediating the ROS signaling (Xiong and Zhu, 2002). It has been reported that ROS has a role in gene activation of peroxy and alkoxy radicals and lipid peroxidation products Spiteller et al., (2001). O2- and H2O2 play a role in signaling that causes variation in the transcript level of Cu/Zn-SOD in Pisum sativum (Pea) under cadmium (Cd) stress (Romero-Puertas et al., 2004). ROS has a role in signaling for acclimation against chilling stress and photo-oxidative stress. Yang et al. (2009) reported the involvement of H2O2 in signaling backed up by its role in infection of proline level. The pre-treatment of H2O2 was reported to enhance the non-enzymatic and enzymatic antioxidants in four species of Digitalis namely D. cariensis, D. davisiana, D. trojana and D. lamarckii (Cingoz et al., 2014).
ABA signaling
Abiotic stresses such as drought and salt stress increase ABA gathering and on external ABA application, plants undergo certain stresses like osmotic stress. To know whether some or all the response of osmotic stress are of ABA dependent, mutants of Arabidopsis such as abi1, abi2 and aba1 and aba2 have been used. Many studies on stress responsive genes showed that some genes are completely ABA dependent while some are completely ABA independent and some others are partially dependent on ABA (Sah et al., 2016; Vishwakarma et al., 2017). The independent and dependent gene regulation of ABA regulated by RD291 gene acts as a superior model. The accumulation of RD29A transcript is partially blocked by abi1 and aba1 as shown by several studies on osmotic stress induction which encourage independent and dependent regulation of ABA. DRE (dehydration responsive element) element sequence in the RD29A gene promoter has been identified by scientist revealing its necessity for induction of osmotic stress. Normally DRE elements cannot be activated by ABA but osmotic stress activated DRE requires ABA, for its activation. ABA role in response to cold stress is still unclear but ABA is believed to have an important role in response to cold. It was reported that there is a temporary accumulation of ABA in response to cold, other studies showed a tiny accumulation of ABA in response to cold. Many studies results showed the external application of ABA to the plant confer tolerance in plants against cold stress Fig 3.

Fig 3: ABA-independent signaling in response to osmotic, heat, cold stress and ABA-dependent signaling channel in response to temperature stress.

ABA-Independent pathways
DREB are the transcription factors that help in inducing genes which are stress-related and provide resistance against various abiotic stresses. DREB1 and DREB2 are the two main group of DREB. Low temperature stress involves DREB1 while dehydration involve DREB2. They come under ERF (ethylene responsive element binding factors) family of transcriptional factors. A preserved 58-59 amino acid region (ERF region) has been shared by the ERF proteins and these regions attach to cis-element which are found in several PR (pathogen related) gene promoters that involve in ethylene response and these regions attach to the DRE (dehydration responsive element) pattern which involve in the dehydration responsive genes (Agarwal et al., 2006). DREB proteins of TFs (transcriptional factors) contains an ERF/AP2DNA-attaching region. The amino acid sequence showed resemblance in the c-terminal acidic region and also at the N-terminal region in nuclear localization signal (Agarwal et al., 2006). ERF /AP2DNA-attaching region are found extensively in plants such as maize, rice, tobacco, tomato and Arabidopsis.
ABA-Dependent pathways
Regulatory protein kinases play an important role in phosphorylation of targets (downstream) which initiate the transcriptional events (Furihata et al., 2006; Johnson et al., 2002; Umezawa et al., 2009). ABA-dependent pathway of signaling depends upon the MYB/MYC transcription family (Abe et al., 2003). ABA regulated 15 genes have been identified, out of which 9 are induced whereas 6 are repressed (Zhang et al., 2012b). It is also reported that out of these 15 genes, 14 genes respond to the osmotic stress which is caused by PEG (Zhang et al., 2012b). Genes TaMYB33 and TaMYB32 helps in the salt tolerance and these genes were overexpressed in the Arabidopsis plant under salt stress (Qin et al., 2012; Zhang et al., 2012a). TaMYB33 also play a major role in the production of antioxidants to detoxify the damaging ROS (Reactive oxygen species) (Qin et al., 2012). External application of salicylic acid and ABA help in the induction of TaPIMP1 MYB and this MYB protein act as a mediator for responses in different type of hormones or acts as an integral point of salicylic and ABA signaling (Zhang et al., 2012a). Some members of the family MYB, namely TaMYB3R1, found to be play an important role in hormonal signaling.

Another family of protein is WRKY-type family of transcription factors have an important role in the ABA-regulated pathway in abiotic stress signaling. A study on this family shows that there are 40 members in this family. TaWRK19 and TaWRKY2 were the two which are characterized in wheat crop and both were induced through various abiotic stresses. TaWRKY19 enhances cold, drought and salt tolerance led by its overexpression (Niu et al., 2012).
Ion Homeostasis (Sodium and Calcium)
There is the propensity of a cell or an entity to regulate its internal stable state in response to different types of environmental disturbance. Hypersaline environment cause disturbance of stable ionic state Cl- and NaCl in addition to Ca2+ and K+. Presence of high amount of sodium (Na+) in the environment has great agricultural importance because saline solutions impose stresses on the plants. Uptake of K+ ion by cells of root found to be disturbed by Na+ ions (Hasegawa et al., 2000). Cell membranes receptor sense the amount of Na+ present externally whereas Na+-sensitive cytoplasmic enzyme or membrane proteins perceive the Na+ present internally (Turkan and Demiral, 2009). Accumulation of excess of Na+ in leaf cells cause toxicity in the production of enzymes (Hasegawa et al., 2000). Presence of high amount of Na+ causes necrosis in the older leaves, which reduce the life span of leaves, resulting in the low productivity (Munns, 2002). Compartmentation of Na+ ions in vacuole decrease the amount of sodium ions in cytoplasm. Presence of membrane transporters in wide range support the plants to fight against external stresses (Maser et al., 2002). Arabidopsis was the first plant in which the cation exchanger (Na+/H+) was found.
Mapkinases stress signaling
The plant MAPK substrate identification is mandatory to understand the mechanism and function of MAPK. Several scientists reported around 700 putative MAPK substrates through targeted experiments and by using the novel approaches such asprotein array screening and phosphoproteomics (Hoehenwarter et al., 2013; Rayapuram et al., 2018). MAPK pathways are the signaling component that are used to transduce cellular signals in the cell (Morrison, 2012). These MAPKs are initialized by phosphorylation (dual) of threonine and tyrosine remnants in a partially unorganized part of the catalytic domain. Threonine remnant phosphorylation guide the hydrogen bond formation on the MAPK surface by joining the amino-terminal with the unorganized part. Tyrosine remnant phosphorylation guide to the formation of new H-bond and refolding of unorganized part to make a structure (Rodriguez Limardo et al., 2011).The JNK and p38 families of MAPK are initialized by the intra and extracellular stress to the cell (Cuadrado and Nebreda, 2010; Davis, 2000).

The phosphorylation of MAPK act as connection between the transcription factors (downstream) and the receptor (Upstream). These MAP Kinases are activated during the various abiotic stresses. MAPK cascade is composed of three protein kinase, which are linked with each other in their function, namely MAPK, MAPKK and MAPKKK (Agarwal et al., 2003). In MAPK cascade firstly MAPK phosphorylate which initiate the specific MAPKK which upon phosphorylation give rise to activation of MAPKKK. This MAPK (activated) moves downstream in to nucleus, phosphorylates and activates the transcriptional factors which give rise to cellular response (Xiong and Yang, 2003).

The p38 of MAPK family encodes four genes which are divided into two main subgroups namely p38 g/d and p38 a/b (Cuadrado and Nebreda, 2010; Cuenda and Rousseau, 2007). TheJNKs of MAPK family coding three genes namely JNK3, JNK2 and JNK 1 which upon splicing give rise to 10 different types of isoforms. Out of these three genes, two genes JNK2 and JNK1 are expressed pervasively but the JNK3 gene expressed firstly in the brain (Davis, 2000). Isoforms of different type of MAPKK initiate specific MAPKs: MKK1 initialize ERK1, MKK2 initialize ERK2, MKK3 initialize p38 whereas MKK4 initialize p38 and JNK, MKK6 and MKK7 initialize p38 and JNK respectively. The MLK (mixed-lineage protein kinase) class of MAPKKKs are initialized by Cdc43 and Rac1 which are the part of Rho GTPase family (Gallo and Johnson, 2002). ATM (ataxia telangiectasia-mutated) protein kinase activates the stress-activated MAPKs in response when there is damage of DNA (Rhind and Russell, 2012). Stress-activated MAPK play an important role in cellular pathology and physiology (Cuadrado and Nebreda, 2010; Davis, 2000). It plays a role in some particular examples like inflammatory stress, cell death and metabolic stress.

Cells when exposed to cytokines such as IL1 and TNF results in the stress-activated MAPKs activation (Lim and Staudt, 2013; Newton and Dixit, 2012). This pathway of activation needs TAB3 and TAB2 (ubiquitin-binding supplement protein) and TAK1 (isoform of MAPKKK). The TAK1 isoform is activated by the TAB proteins jointly with the K63-linked polyubiquitin chains (Chen, 2012). The IL1 receptor create autoubiquitylation (K-63 linked) of E3 ligase TRAF6 and receptor of TNF create ubiquitylation (K63-linked) of TRAF2/5 and RIP1 by E3 ligases cIAPI/2 (Lim and Staudt, 2013; Newton and Dixit, 2012).
Salt overly sensitive (SOS) signaling
Salinity tolerance in plants include the activation of signaling pathways namely salt overly sensitive (SOS) signaling (Ji et al., 2013). To alleviate the effect of various abiotic stresses, different pathways of signaling have been reported but none of them were perceive in proteins signaling terms. The results obtained from molecular, biochemical and genetic analysis were found to be different from the SOS pathway which makes the SOS pathway an exceptional pathway (Zhu, 2001). Salt-elicited calcium signal is sensed by a myristoylated calcium-binding protein and then convert it for the downstream responses. SOS1, which is a salt tolerance effector gene, was regulated by SOS3 and SOS2. The transport activity of SOS1 was activated with the help of SOS3 and SOS2 (Qui et al., 2001). SOS genes are found to co-express itself and have a role in response to salinity stress in Arabidopsis plant (Ma et al., 2014). A study on the plasma membrane Na+/H+ exchanger in rice crop reveals that the SOS1 gene have a significant role in adaptive response to salinity stress (El-Mahi et al. 2019). SOS2 belong to a PKS family of proteins which is found only in plants (Guo et al., 2001). SOS2 contains two domains namely unique regulatory domain and SNF1-like catalytic domain which interact with SOS3. The domains of SOS2 interacts with each other for keeping the kinase inactivated. Attaching of regulatory domain with the SOS3 appears to damage the SOS2 intramolecular interactions which leads to opening of catalytic site (Guo et al., 2001).

SOS3 belongs to new subfamily of calcium binding proteins. These proteins are very similar with type 2B protein phosphatase (B-subunit of calcineurin) (Guo et al., 2001).  It is also found that some of the SOS3 proteins in plant cells are not related with membranes as they are compatible with the nonmembrane-bound protein which target the SOS2-SOS3 complex (Ishitanim et al., 2000).
Transcription factors (TFS) in abiotic stress signaling
Transcription factors (TFs) are major regulators controlling the expression of gene and have a crucial role in development of plant, cell signaling, response to stress and cell cycling (Gonzalez et al., 2016). The pathways of signal transduction carry signal of stress to the end point of stress responsive expression of gene of signal transduction pathway.  The pathway contains various cis-acting elements as well as transcription factors which are having a role in response to stress. There are two methods to improve the plants efficiency to withstand against various stresses. First managing the process of ion transport and reorganizing of the primary metabolism. Secondly changing and regulating the pathways of signaling. Out of these two second approach is more helpful because signaling components such as translational and transcriptional consist regulatory factors (Golldack et al., 2011; Singh et al., 2021b, c). Several TFs have been investigated which gave response to stresses with the help of molecular tools such as transcriptomics, functional genomics and proteomics in several crops including sugarcane (Mustafa et al., 2018). Transcription factors have been classified into two classes in response to drought stress and these are ABA dependent and ABA independent transcription factors (Gujjar et al., 2014).

DREB family of transcription factors are having an important role in response to various abiotic stresses (Gutha and Reddy, 2008). They are found tohelp in the activation of genes such as cro15A and rd2 9A which helps the transgenic plants to withstand against high salinity and drought conditions. DREB TFs have been classified into two classes namely DREB1 and DREB2. DREB1 have been involved under low temperature while DREB2 has been involved under dehydration in the signal transduction pathway (Agarwal et al., 2006). It has been reported that DREB2A and DREB2B are the analogous TFs which act as stress responsive genes.

bZIP (basic leucine zipper) proteins have a bZIP domain having 40-80 amino acids preserved domain consisting two structures, one, the region for the attachment of transcription factors and the otherneeded for the dimerization of TFs called as leucine zipper (Nijhawan et al., 2008). The bZIP family of TFs helps in the regulation of various mechanisms such as tissue differentiation, seed storage protein gene regulation, osmotic control, energy metabolism, pathogen defense, sugar and hormone signaling, light response, unfolded protein response and cell regulation (Nijhawan et al. 2008). It has been reported that the bZIP proteins have a crucial role in response to salinity stress (Das et al., 2019; Liang et al., 2016; Liu et al., 2014; Zhu et al., 2018).

MYB family of TFs has an important role in mechanism of biotic and abiotic stress, development and metabolism. Among all R2R3-MYB family is the largest family of MYB which is present in the plants (Dubos et al., 2010; Millard et al., 2019; Li et al., 2019b). Many genes have been identified from MYB family (Zhang et al., 2012).

WRKY family of transcription factors have WRKYGQK sequences which bind with W-BOX (TTGAC) at the promoter. WRKY family have large number of transcription factors which are indicated by the presence of chain of 60 amino acids (Shimono et al., 2007). This family is the large family of transcription factors composed of 90 members in rice and 74 members in arabidopsis (Eulgem and Somssich, 2007; Ulker and Somssich, 2004). The WRKY proteins are divided into three groups on the basis of zinc finger motifs and WRKY domain numbers (Ulker and Somssich, 2004). WRKY alone can’t associate in stress like other MYB and AP2-EREBPs, but this WRKYs are expressed when they are in combination i.e., biotic as well as abiotic stress (Bai et al., 2018). A number of WRKY family TFs have been identified in several plant species as shown in the Table 1.

Table 1: A number of WRKY TFs identified in plant species.

NAC transcription factors have important role in salinity stress. This family of TFs contains domain such as NAM (no apical meristem), CUC2 (cup-shaped cotyledon) and ATAF1-2. Arabidopsis has 106 whereas rice has 149 NAC family transcription factors (Gong et al., 2004; Xiong et al., 2005). The domain of NAC consists of 150-160 residues and classified in to five subdomains i.e. A to E (Ooka et al., 2003). It is also reported that these NAC transcription factors also play arole in controlling the various processes such as flowering, biotic stress, anther dehiscence, abiotic stress and lateral root development (Gujjar et al., 2014). CaNAC064, which is a NAC transcription factor was reported to have a capability to resist the cold stress when they interact with haplo-protein which were induced during low temperature conditions (Hou et al., 2020). Over expression of EcNAC67 TF in transgenic rice exhibit lower spikelet sterility, higher seedling vigour and increased performance in tolerance to stress caused by drought (Rahman et al., 2016).
Signaling pathways and the cross-talk between several pathways plays a very impressive role in plant abiotic stress responses. Stress responsive genes involvement in several metabolic approaches to emphasize the tolerance against stress in plants has common implications. More efforts are still essential to know much about the outcome of each gene which is persuaded by ABA and its association arrangement to recognize the complexity of salinity stress pathways of signaling. We still need to know about the different types of ABA-responsive genes. As the new powerful appliance viz, proteomics, genomics and transcriptomics are appearing, understanding these signaling will improve and provide pathways to tolerate various stresses. Genetic engineering now a days play a crucial role in signal study but understanding the mechanism of each and every gene action are still to be achieved.
Author’s contribution
All the authors have equal contribution in writing a manuscript.
Ethics approval: NA.
Consent to participate: NA.
Consent for publication: NA.
The authors declare that they have no conflict of interests.

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