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Current IssueEditorial BoardOnline First ArticlesArchive
Current IssueEditorial BoardOnline First ArticlesArchive

Reviewer Article

volume 38 issue 4 (december 2017) : 282-289,   Doi: 10.18805/ag.R-1741

Lycopene and human health-A review

G
Gurpreet Kaur
A
Anupama Sandal
N
Navjot Singh Dhillon
1Department of Food Science, Nutrition and Technology, Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya, Palampur-176 062, Himachal Pradesh, India
Cite article:- Kaur Gurpreet, Sandal Anupama, Dhillon Singh Navjot (2017). Lycopene and human health-A review. Agricultural Reviews. 38(4): 282-289. doi: 10.18805/ag.R-1741.

ABSTRACT

Functional and nutraceutical foods have shared the disease load of huge population. This has led to the consumption of plant-based phytonutrients act as preventives agents when taken as dietary supplements. Their health promoting potentials are due to presence of functional ingredients. The antioxidant properties of lycopene are thought to be primarily responsible for its beneficial properties. Lycopene bioavailability, tissue distribution, metabolism, excretion, and biological actions in humans are beginning to accumulate although much additional research is necessary. Lycopene is an important carotenoids.These are found to be very beneficial for maintaining a good health and helps in preventing cancer, cardiovascular and other diseases.

REFERENCES

  1. Akhtar,S., Ahmed, A., Randhawa, M.A. (2013). Prevalence of vitamin A deficiency in South Asia: causes, outcomes and possibleremedies, Journal of Health, Population, and Nutrition, 31:413–423.
  2. Alipanah,N., Varadhan, R., Sun, K., Ferrucci, L., Fried, L.P. and Semba,R.D.(2009). Low serum carotenoids are associated with a decline in walking speed in older women, Journal of Nutrition, Health and Aging,13: 170–176.
  3. Altan, A., McCarthy, K.L, Maskan, M. (2008). Evaluation of snack foods from barley-tomato pomace blends by extrusion processing, J Food Eng, 84: 231–242.
  4. Anese, M., Manzocco, L., Nicoli, M.C., Lerici, C.R. (1999). Antioxidant properties of tomato juice as affected by heating, J Sci Food Agric, 79: 750-754.
  5. Arab, L., Steck, S. (2000). Lycopene and cardiovascular disease. Am J Clin Nutr, 71(6):1691S–95S.
  6. Aust, O., Stahl,W., Sies, H., Tronnier, H., Heinrich, U.(2005). Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res,75(1):54–60
  7. Badimon, L., Vilahur, G. and Padro, T. (2010). Nutraceuticals and atherosclerosis: human trials. Cardiovasc. Ther, 28(4):202–215
  8. Basu, A., Imrhan, V. (2007). Tomatoes versus Lycopene in oxidative stress and carcinogenesis: conclusion from clinical trials. Eur J ClinNutr, 61 (3): 295-303.
  9. Benakmoum, A., Abbeddou, S., Ammouche, A., Kefalas, P., Gerasopoulos, D.(2008). Valorisation of low quality edible oil with tomato peel waste, Food Chem, 110: 684–690.
  10. Bohn, T., Blackwood, M., Francis, D., Tian, Q., Schwartz, S.J., Clinton, S.K. (2009).Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials. 
  11. Bohn,T. (2014). Dietary factors affecting polyphenol bioavailability, Nutrition Reviews, 72(7):429–452.
  12. Butt, M. S., Nazir, A., Sultan, M. T. and Schro¨en, K. (2008). Morus alba L. Nature’s functional tonic. Trends in Food Sci. Technol, 19:505–512.
  13. Butt, M.S., Sultan, M.T., Butt, M.S., Iqbal, J. (2009). Garlic: Nature’s protection against physiological threats. Crit Rev Food Sci Nutr 49:538-51.
  14. Calvo, M.M., García, M.L, Selgas, M.D. (2008). Dry fermented sausages enriched with lycopene from tomato peel, Meat Sci, 80: 167–172.
  15. Chandra, R.V., Prabhuji, M.L., Roopa, D.A., Ravirajan, S., Kishore, H.C. (2007). Efficacy of lycopene in the treatment of gingivitis: a randomized, placebo-controlled clinical trial. Oral Health Prev Dent,5(4):327–36
  16. Chen, L., Stacewicz-Sapuntzakis, M., Duncan, C., Sharifi, R., Ghosh, L. (2001). Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst; 93(24):1872–79
  17. Cho, E., Seddon, J.M., Resoner, B., Willett, W.C., Hankinson, S.E. (2004). Prospective study of intaske of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol, 122(6): 883-92.
  18. Clinton, S.K. (1998). Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev, 56(2):35–51
  19. Clinton, S.K., Emenhiser, C., Schwartz, S.J., Bostwick, D.G., Williams, A.W., Moore, B.J., Erdman, J.W. (1996). Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, Cancer Epidemiol Biomark Prev, 5(10): 823–833.
  20. Cox, B.D., Whichelow, M.J. and Prevost, A.T. (2000) Seasonal consumption of salad vegetables and fresh fruit in relation to the development of cardiovascular disease and cancer. Public Health Nutrition 3: 19-29
  21. Cumming, R.G, Mitchell, P., Smith, W. (2000).Diet and cataract: The blue Mountains Eye studies, Ophthalmology, 107:450–456.
  22. Dahan, K., Fennal, M., Kumar, N.B. (2008). Lycopene in the prevention of prostate cancer. J Soc Integr Oncol,6(1):29–36
  23. Davidsson, L.and Haskell, M. (2011). “Bioavailability of micronutrients: stable isotope techniques to develop effective food-based strategies to combat micronutrient deficiencies, “Food and Nutrition Bulletin,32: S24–S30.
  24. Dhas, P.H.A., John Zachariah, T., Rajesh, P.N, Subramannian, S.(2004). Effect of blanching and drying on quality of mace (Myristica Fragrans), J Food Sci Technol: 306–308
  25. Dias, I.H.K., Polidori,M.C.,Lietal,L.(2014).”Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities, “Journal of Alzheimer’s Disease, 40(2): 399–408.
  26. During, A., Harrison, E.H.(2004). Intestinal absorption and metabolism of carotenoids: insights from cell culture. Arch Biochem Biophys; 430(1):77–88.
  27. Ellinger, S., Ellinger, J., Stehle, P.(2006).Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?, Clinical Mutrition and Metabolic Care; 9(6):722–727.
  28. Fabian, E., Elmadfa, I. (2007).The effect of daily consumption of probiotic and conventional yoghurt on oxidant and anti-oxidant parameters in plasma of young healthy women. Int J Vitam Nutr Res, 77(2):79–88.
  29. Foy, C.J., Passmore, A.P., Vahidassr, M.D., Young, I.S., Lawson, J.T.(1999). Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia and Parkinson’s disease, QJM, 92: 39-45.
  30. Furr, H.C., Clark, R.M. (1997). Intestinal absorption and tissue distribution of carotenoids. J Nutr Biochem, 8(7):364–77.
  31. Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiological literature. J Natl Cancer Inst; 91(4):317–31
  32. Goralczyk, R., Siler, U. (2004). The Role of Lycopene in Human Health. In Phytochemicals in Health and Disease; Bao Y, Fenwick R, Eds.; Marcel Dekker Inc: New York, NY, USA, 285–309. 
  33. Gu, Y., Ajay, S., Sharmila, B. and Neena, S. (2008). Pathogenic mutations in the glycosylphosphatidylinositol signal peptide of PrP modulate its topology in neuroblastoma cells. Mol. Celluar Neurosci, 4(37):647–656.
  34. Gunasekera, R.S., Sewgobind, K., Desai, S., Dunn, L., Black, H.S., McKeehan, W.L., Patil, B.(2007). Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells ,Nutr Cancer;58(2):171-5
  35. Gupta,S.K,, Trivedi, D., Srivastava, S., Joshi, S., Halder, N., Verma, S.D.(2003). Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study, Nutr, 19: 794-799
  36. Johnson, E.J., Qin, J., Krinsky, N.I., Russell, R.M. (1997).Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. J Nutr, 127(9):1833–37.
  37. Knoblich, M., Anderson, B., Latshaw, D.(2005).Analyses of tomato peel and seed byproducts and their use as a source of carotenoids, J Sci Food Agric, 85: 1166–1170
  38. Krishna, G. (1985). Carotene and tocopherol in agro-industrial by-products and wastes of the tropics, Agric Wastes, 12: 235–239.
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  42. Longnecker, M.P., Kamel, F., Umbach, D.M., Munsat, T.L., Shefner, J.M., Lansdell, L.W., Sandler, D.P. (2000). Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis, Neuroepidemiology, 19: 210-216.
  43. Lucarini, M., Lanzi, S., D’Evoli, L., Aguizzi, A.(2006). Lombardi-Boccia G. Intake of vitamin A and carotenoids from the Italian population–results of an Italian total diet study. Int J Vitam Nutr Res,76(3):103–9
  44. Manach, C., Scalbert, A., Morand, C., R´em´esy, C. and Jim´enez, L. (2004). Polyphenols: Food sources and bioavailability. Americ. J. Clin. Nutri,79:727–747.
  45. Mariani,S., Lionetto, L., Cavallari, M. et al. (2014). “Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia,” International Journal of Molecular Sciences, 15:1433–1440.
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    Reviewer Article

    volume 38 issue 4 (december 2017) : 282-289,   Doi: 10.18805/ag.R-1741

    Lycopene and human health-A review

    G
    Gurpreet Kaur
    A
    Anupama Sandal
    N
    Navjot Singh Dhillon
    1Department of Food Science, Nutrition and Technology, Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya, Palampur-176 062, Himachal Pradesh, India
    Cite article:- Kaur Gurpreet, Sandal Anupama, Dhillon Singh Navjot (2017). Lycopene and human health-A review. Agricultural Reviews. 38(4): 282-289. doi: 10.18805/ag.R-1741.

    ABSTRACT

    Functional and nutraceutical foods have shared the disease load of huge population. This has led to the consumption of plant-based phytonutrients act as preventives agents when taken as dietary supplements. Their health promoting potentials are due to presence of functional ingredients. The antioxidant properties of lycopene are thought to be primarily responsible for its beneficial properties. Lycopene bioavailability, tissue distribution, metabolism, excretion, and biological actions in humans are beginning to accumulate although much additional research is necessary. Lycopene is an important carotenoids.These are found to be very beneficial for maintaining a good health and helps in preventing cancer, cardiovascular and other diseases.

    REFERENCES

    1. Akhtar,S., Ahmed, A., Randhawa, M.A. (2013). Prevalence of vitamin A deficiency in South Asia: causes, outcomes and possibleremedies, Journal of Health, Population, and Nutrition, 31:413–423.
    2. Alipanah,N., Varadhan, R., Sun, K., Ferrucci, L., Fried, L.P. and Semba,R.D.(2009). Low serum carotenoids are associated with a decline in walking speed in older women, Journal of Nutrition, Health and Aging,13: 170–176.
    3. Altan, A., McCarthy, K.L, Maskan, M. (2008). Evaluation of snack foods from barley-tomato pomace blends by extrusion processing, J Food Eng, 84: 231–242.
    4. Anese, M., Manzocco, L., Nicoli, M.C., Lerici, C.R. (1999). Antioxidant properties of tomato juice as affected by heating, J Sci Food Agric, 79: 750-754.
    5. Arab, L., Steck, S. (2000). Lycopene and cardiovascular disease. Am J Clin Nutr, 71(6):1691S–95S.
    6. Aust, O., Stahl,W., Sies, H., Tronnier, H., Heinrich, U.(2005). Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res,75(1):54–60
    7. Badimon, L., Vilahur, G. and Padro, T. (2010). Nutraceuticals and atherosclerosis: human trials. Cardiovasc. Ther, 28(4):202–215
    8. Basu, A., Imrhan, V. (2007). Tomatoes versus Lycopene in oxidative stress and carcinogenesis: conclusion from clinical trials. Eur J ClinNutr, 61 (3): 295-303.
    9. Benakmoum, A., Abbeddou, S., Ammouche, A., Kefalas, P., Gerasopoulos, D.(2008). Valorisation of low quality edible oil with tomato peel waste, Food Chem, 110: 684–690.
    10. Bohn, T., Blackwood, M., Francis, D., Tian, Q., Schwartz, S.J., Clinton, S.K. (2009).Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials. 
    11. Bohn,T. (2014). Dietary factors affecting polyphenol bioavailability, Nutrition Reviews, 72(7):429–452.
    12. Butt, M. S., Nazir, A., Sultan, M. T. and Schro¨en, K. (2008). Morus alba L. Nature’s functional tonic. Trends in Food Sci. Technol, 19:505–512.
    13. Butt, M.S., Sultan, M.T., Butt, M.S., Iqbal, J. (2009). Garlic: Nature’s protection against physiological threats. Crit Rev Food Sci Nutr 49:538-51.
    14. Calvo, M.M., García, M.L, Selgas, M.D. (2008). Dry fermented sausages enriched with lycopene from tomato peel, Meat Sci, 80: 167–172.
    15. Chandra, R.V., Prabhuji, M.L., Roopa, D.A., Ravirajan, S., Kishore, H.C. (2007). Efficacy of lycopene in the treatment of gingivitis: a randomized, placebo-controlled clinical trial. Oral Health Prev Dent,5(4):327–36
    16. Chen, L., Stacewicz-Sapuntzakis, M., Duncan, C., Sharifi, R., Ghosh, L. (2001). Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst; 93(24):1872–79
    17. Cho, E., Seddon, J.M., Resoner, B., Willett, W.C., Hankinson, S.E. (2004). Prospective study of intaske of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol, 122(6): 883-92.
    18. Clinton, S.K. (1998). Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev, 56(2):35–51
    19. Clinton, S.K., Emenhiser, C., Schwartz, S.J., Bostwick, D.G., Williams, A.W., Moore, B.J., Erdman, J.W. (1996). Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, Cancer Epidemiol Biomark Prev, 5(10): 823–833.
    20. Cox, B.D., Whichelow, M.J. and Prevost, A.T. (2000) Seasonal consumption of salad vegetables and fresh fruit in relation to the development of cardiovascular disease and cancer. Public Health Nutrition 3: 19-29
    21. Cumming, R.G, Mitchell, P., Smith, W. (2000).Diet and cataract: The blue Mountains Eye studies, Ophthalmology, 107:450–456.
    22. Dahan, K., Fennal, M., Kumar, N.B. (2008). Lycopene in the prevention of prostate cancer. J Soc Integr Oncol,6(1):29–36
    23. Davidsson, L.and Haskell, M. (2011). “Bioavailability of micronutrients: stable isotope techniques to develop effective food-based strategies to combat micronutrient deficiencies, “Food and Nutrition Bulletin,32: S24–S30.
    24. Dhas, P.H.A., John Zachariah, T., Rajesh, P.N, Subramannian, S.(2004). Effect of blanching and drying on quality of mace (Myristica Fragrans), J Food Sci Technol: 306–308
    25. Dias, I.H.K., Polidori,M.C.,Lietal,L.(2014).”Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities, “Journal of Alzheimer’s Disease, 40(2): 399–408.
    26. During, A., Harrison, E.H.(2004). Intestinal absorption and metabolism of carotenoids: insights from cell culture. Arch Biochem Biophys; 430(1):77–88.
    27. Ellinger, S., Ellinger, J., Stehle, P.(2006).Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?, Clinical Mutrition and Metabolic Care; 9(6):722–727.
    28. Fabian, E., Elmadfa, I. (2007).The effect of daily consumption of probiotic and conventional yoghurt on oxidant and anti-oxidant parameters in plasma of young healthy women. Int J Vitam Nutr Res, 77(2):79–88.
    29. Foy, C.J., Passmore, A.P., Vahidassr, M.D., Young, I.S., Lawson, J.T.(1999). Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia and Parkinson’s disease, QJM, 92: 39-45.
    30. Furr, H.C., Clark, R.M. (1997). Intestinal absorption and tissue distribution of carotenoids. J Nutr Biochem, 8(7):364–77.
    31. Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiological literature. J Natl Cancer Inst; 91(4):317–31
    32. Goralczyk, R., Siler, U. (2004). The Role of Lycopene in Human Health. In Phytochemicals in Health and Disease; Bao Y, Fenwick R, Eds.; Marcel Dekker Inc: New York, NY, USA, 285–309. 
    33. Gu, Y., Ajay, S., Sharmila, B. and Neena, S. (2008). Pathogenic mutations in the glycosylphosphatidylinositol signal peptide of PrP modulate its topology in neuroblastoma cells. Mol. Celluar Neurosci, 4(37):647–656.
    34. Gunasekera, R.S., Sewgobind, K., Desai, S., Dunn, L., Black, H.S., McKeehan, W.L., Patil, B.(2007). Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells ,Nutr Cancer;58(2):171-5
    35. Gupta,S.K,, Trivedi, D., Srivastava, S., Joshi, S., Halder, N., Verma, S.D.(2003). Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study, Nutr, 19: 794-799
    36. Johnson, E.J., Qin, J., Krinsky, N.I., Russell, R.M. (1997).Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. J Nutr, 127(9):1833–37.
    37. Knoblich, M., Anderson, B., Latshaw, D.(2005).Analyses of tomato peel and seed byproducts and their use as a source of carotenoids, J Sci Food Agric, 85: 1166–1170
    38. Krishna, G. (1985). Carotene and tocopherol in agro-industrial by-products and wastes of the tropics, Agric Wastes, 12: 235–239.
    39. Lenore, A. and Susan, S.(2007). Lycopene and cardiovascular diseases.American journal of clinical nutrition, 71: 691-5.
    40. Levy, J., Ben- Dor, A., Dubi, N., Danilenko, M., Zick, A., Sharoni, Y. (2004) Carotenoids activate the antioxidant response element (are) transcription system. AACR Annual Meeting.
    41. Lindshield, B. L., Canene-Adams, K. and Erdman, J. W. (2007). Lycopenoids: Are lycopene metabolites bioactive? Arch. Biochem. Biophys,458(2):136–140.
    42. Longnecker, M.P., Kamel, F., Umbach, D.M., Munsat, T.L., Shefner, J.M., Lansdell, L.W., Sandler, D.P. (2000). Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis, Neuroepidemiology, 19: 210-216.
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