Agricultural Reviews

  • Chief EditorPradeep K. Sharma

  • Print ISSN 0253-1496

  • Online ISSN 0976-0741

  • NAAS Rating 4.84

Frequency :
Quarterly (March, June, September & December)
Indexing Services :
AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Research Article

Agricultural Reviews, volume 37 issue 3 (september 2016) : 250-254

Growth Hormone Receptor (GHR) gene and its applications in livestock: A review

Anamika, Dibyendu Chakraborty*, D. Kumar, Peer Mohd. Azhar, S. Gurdeep Singh, Simran singh, Aakriti Sudan
1<p>Division of Animal Genetics &amp; Breeding,&nbsp;FVSc&amp;AH, SKUAST-Jammu, R. S. Pura-181 102, Jammu, India.</p>
Cite article:- Anamika, Chakraborty* Dibyendu, Kumar D., Azhar Mohd. Peer, Singh Gurdeep S., singh Simran, Sudan Aakriti (2016). Growth Hormone Receptor (GHR) gene and its applicationsin livestock: A review . Agricultural Reviews. 37(3): 250-254. doi: 10.18805/ag.v37i3.3541.

ABSTRACT

The Growth Hormone Receptor (GHR) gene provides instructions for making a protein called the growth hormone receptor. The GHR mediates biological actions of growth hormone on target cells by transducing the growth hormone (GH) signal across the cell membrane and inducing transcription of many genes, including insulin-like growth factor-1 (IGF1). The gene coding for bovine GHR gene consists of nine exons. In exon 8 of the bovine GHR gene, T/A nucleotide variation results in to change in tyrosine from phenylalanine in the transmembrane domain of the GHR protein, has been reported to be associated with a major effect on milk yield in cows. GHR (growth hormone receptor) gene has been shown to harbor a causal mutation of a QTL influencing milk yield and composition GHR gene is a polymorphic gene and the polymorphisms are related to different economic traits of different species. The GHR gene influences physical traits and helps to selection of animals. The lengths of the variable TG-repeats in the P1 promoter of the bovine GHR gene are associated with growth rates in young Angus cattle. Due to various functions of GHR are viewed as promising candidate markers for selection purposes in cattle. Thus GHR gene could be a candidate gene for application in marker assisted selection (MAS).

REFERENCES


  1. Adkins, R. M., Gelke, E. L., Rowe,D. and Honeycutt, R. L. (2001). Molecular phylogeny and divergence time estimates for major rodent groups: Evidence from multiple genes. Mol. Biol. Evol.,18: 777-791.

  2. Aggrey, S.E., Yao, J., Lin, C.Y., Zadworny, D., Hayes, F.J. and Kuhnlein,U. (1999). Markers within the regulatory region of the growth hormone receptor gene and their association with milkrelated traits in holsteins. Journal of Heredity,90:148 151.

  3. Akad, I. A., Mengi, A. and Oztabak, K. O. (2012). A determination of growth hormone receptor gene polymorphisms in East Anatolian Red cattle, South Anatolian Red cattle, and Turkish Grey cattle Turk. J. Vet. Anim. Sci., 36:27-33. 

  4. Akers, R. M., Bauman, D.E., Capuco, A.V., Goodman, G.T. andTucker, H.A. (1981). Prolactin regulation of milk secretion andbiochemical differentiation of mammary epithelial cells inperiparturient cows. J. Endocrinol, 109:23.

  5. Argetsinger, L.S. and Carters, U.C. (1996). Growth hormone signalling mechanisms: involvement of the tyrosine kinase JAK2. Hormone Research, 45:22-24.

  6. Bahrami, A., Behzadi, Sh., Miraei-Ashtiani, S. R., Roh, S.-G. and Katoh, K. (2013). Genetic polymorphisms and protein structures in growth hormone, growth hormone receptor, ghrelin, insulin-like growth factor 1 and leptin in Mehraban sheep. Gene, http://dx.doi.org/10.1016/j.gene.2013.05.066.

  7. Bai, W. L., Zhou, C. Y., Ren, Y., Yin, R. H., Jiang, W. Q., Zhao, S. J., Zhang, S. C., Zhang, B. L., Luo, G. B. and Zhao, Z. H. (2011). Characterization of the GHR gene genetic variation in Chinese indigenous goat breeds. Molecular Biology Reports, 38: 471-479.

  8. Blanga-Kanfi, S., Miranda, H., Penn, O., Pupko, T., DeBry, R. W. and Huchon, D. (2009). Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades. BMC Evol. Biol., 9: 71. 

  9. Blott, S., Kim, J.J., Moisio, S., Schmidt-Ku¨ntzel, A., Cornet, A., Berzi, P., Cambisano, N., Ford, C., Grisart, B., Johnson, D., Karim, L., Simon, P., Snell, R., Spelman, R., Wong, J., Vilkki, J., Georges, M., Farnir, F. and Coppieters, W. (2003). Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition. Genetics, 163: 253–266.

  10. Burton, J.L., Mcbride, B.W., Block, E., Glimm, D.R. and Kenelly, J.J. (1994). A review of bovine growth hormone. Canadian Journal of Animal Science, 74:167 201.

  11. Curi, R. A., de Oliveira, H. N., Silveira, A. C. and Lopes, C. R. (2005). Effects of polymorphic microsatellites in the regulatory region of IGF1 and GHR on growth and carcass traits in beef cattle. Animal Genetics, 36: 58–62.

  12. Deepika, and Salar, R.K. (2013). Polymorphism studies of growth hormone receptor (GHR) gene in indigenous grey cattle breeds of India. DHR Intl. J. Biomedical and Life Sci., 4:2.

  13. Di Stasio, L., Destefanis, S., Brugiapaglia, A., Albera, A. and Rolando, A. (2005). Polymorphism of the GHR gene in cattle and relationships with meat production and quality. Anim. Genet., 36:138–140. 

  14. Falaki, M., Gengler, N., Sneyers, M.,Prandi, A., Massart, S., Formigoni, A.,Burny, A.,Portetelle, D., Renaville, R., (1996). Relationships of polymorphisms for growth hormone and growth hormone receptor genes with milk production traits for Italian Holstein-Friesian bulls. J. Dairy Sci., 79:1446-1453. 

  15. Ge, W., Davis, M.E., Hines, H.C. and Irvin, K.M. (2000). Single nucleotide polymorphism detected in exon 10 of the bovine growth hormone receptor gene. J Anim. Sci., 78:2229-2230.

  16. Hale, C. S., Herring, W. O., Shibuya, H., Lucy, M. C., Lubahn, D. B., Keisler, D. H. and Johnson, G. S. (2000). Decreased growth in Angus steers with a short TG-microsatellite allele in the P1 promoter of growth hormone receptor gene. J. Anim. Sci., 78: 2099-2104.

  17. https://en.wikipedia.org/wiki/Growth_hormone_receptor

  18. Hussain, D. A. (2015). Molecular Characterization of Some Productive Traits in Mesopotamian Buffaloes (Bubalusbubalis). European Journal of Molecular Biotechnology, 8: 80-87.

  19. Janmeda, M. and Vataliya, P.H. (2014). Molecular study of growth hormone and growth hormone receptor genes in Mehsana buffalo. Ind. J. Vet. & Anim. Sci. Res., 43: 261-266.

  20. Jiang, H.L. and Lucy, M.C. (2001). Variants of the 5’untranslated region of the bovine growth hormone receptor mRNA: isolation, expression and effects on translational efficiency. Gene, 265:45-53.

  21. Lucy, M.C., Johnsson, G.S., Shibuya, H., Boyd, C.K., Herring, W.O. and Werin, M. (1998). Rapid communication: Polymorphic (GT)n microsatellite in the bovine somatotropin receptor gene promoter. Journal of Animal Science,76:2209-2210.

  22. Maj, A., Strza³kowska, N., Sloniewski, K., Krzy¿ewski, J., Oprzadek, J. and Zwierzchowski, L. (2004). Single nucleotide polymorphism (SNP) in the 52 -noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle.Czech Journal of Animal Science, 49: 419-429.

  23. Maj, A., Pareek, C., Klauziñska, M. and Zwierzchowski, L. (2005). Structure and polymorphism of the 5’-noncoding region of the bovine growth hormone receptor gene. J. Anim. Breed. Genet., 122: 414-417.

  24. Maj, A. and Zwierzchowski, L. (2006). Molecular evolution of coding and non-coding sequences of the growth hormone receptor (GHR) gene in the family Bovidae. Folia biol.(Kraków), 54: 31-36.

  25. Maj, A. and Zwierzchowski, L. (2008). Nucleotide sequence polymorphisms in the promoter region of bovine growth hormone receptor gene (GHR) have no effect on its expression level in liver. Animal Science Papers and Reports, 26: 5-15.

  26. Moody, D. E., Pomp, D., Barendse, W. and Womack, J.E. (1995). Assignment of the growth hormone receptor gene to bovine chromosome20 using linkage analysis and somatic cell mapping. Anim. Genet., 26:341–343.

  27. Oleñski, K., Suchocki, T. and Kamiñski, S. (2010). Inconsistency of associations between growth hormone receptor gene polymorphism and milk performance traits in Polish Holstein-Friesian cows and bulls. Animal Science Papers and Reports, 28: 229-234.

  28. Othman, O. E., Abdel-Samad, M. F., El-Maaty, N. A. A., and Sewify, K. M. (2012). Evaluation of DNA Polymorphism in Egyptian Buffalo Growth Hormone and Its Receptor Genes. Journal of Applied Biological Sciences, 6: 37-42.

  29. Pariset, L., Cappuccio, I., Marsan, I., Bruford, M. and Dunner, A. (2006). Characterization of 37 breed-specific single nucleotide polymorphisms in Sheep. J. Hered., 97: 531-534. 

  30. Parmentier, I., Portetelle, D., Gengler, N., Prandi, A., Bertozzi, C., Vleurick, L., Gilson, R. and Renaville, R. (1999). Candidate gene markers associated with somatotropic axisand milk selection. Domestic Animal Endocrinology, 17:139-148.

  31. Rahbar, R., Rahimi, G., Ansari Pirsaraei, Z. and Gholizadeh,M. (2010). Identification of polymorphism in promoter region of growth hormone receptor (GHR) gene and its association with milk related traits in Holstein cows. Afr. J. Biotechnol., 9: 5460-5464. 

  32. Rotwein, P., Gronowski, A. M. and Thomas, M. J. (1994). Rapid nuclear actions of growth hormone. Hormone Research, 42: 170-1755.

  33. Valeh, M. V., Tahmoorespour, M., Ansari, M., Nassiry, M. R., karimi, D. and Taheri, A. 2009. Association of growth traits with SSCP polymorphisms at the Growth Hormone Receptor (GHR) and Growth Hormone Releasing Hormone Receptor (GHRHR) genes in the Baluchi sheep. J. Anim. Vet. Adv., 8: 1063-1069.

  34. Viitala, S. M., Szyda, J., Blott, S., Schulman, N., Lidauer, M., Maki-Tanila, A., Georges, M. and Vilkki, J. (2006). The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Aryshire dairy cattle. Gene, 173: 2151-2164. 

  35. Zulkharnaima, A., Jakariab, B. and Noorb, R. (2010). Identification of genetic diversity of growth hormone receptor (GHR|Alu I) gene in Bali Cattle. Media Peternakan, 33: 81-87.

     
Reviewed By

Download Article
In this Article
    Contact us
    Follow us

    Editorial Board

    View all (0)