Agricultural Reviews

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Agricultural Reviews, volume 36 issue 4 (december 2015) : 327-332

Acute Phase Proteins: How they portray Mastitis – A review

Pramod Kumar, Aasif Ahmad Sheikh*, Thulasiraman Parkunan, Mohammad Rayees Dar, Lakshmi Priyadarshini, Manju G Preedaa1, Gunjan Baghel, Sohan Vir Singh
1<p>Dairy Cattle Physiology Division, National Dairy Research Institute,&nbsp;Karnal-132001, Haryana, India.</p>
Cite article:- Kumar Pramod, Sheikh* Ahmad Aasif, Parkunan Thulasiraman, Dar Rayees Mohammad, Priyadarshini Lakshmi, Preedaa1 G Manju, Baghel Gunjan, Singh Vir Sohan (2015). Acute Phase Proteins: How they portray Mastitis &ndash; A review . Agricultural Reviews. 36(4): 327-332. doi: 10.18805/ag.v36i4.6692.

ABSTRACT

Acute Phase Proteins are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). APR to disease is accompanied by an increase in the circulating concentration of a number of plasma proteins which are collectively known as the Acute Phase Proteins. According to the concentration, APPs are classified in positive APP, if they increase or negative APP, if they decrease. During mastitis, APPs move from the systemic circulation to mammary gland or there could be de-novo synthesis of the APP within mammary gland tissues.  Among the APPs, Serum Amyloid A (SAA), Haptoglobin (Hp), Alpha 1-acid glycoprotein and Lipopolysaccharide binding protein play a major role during mastitis in cattle and their concentration will increase with the severity of the infection, inflammation or trauma. SAA is involved in defense against Gram positive and Gram negative pathogens. SAA acts by modulating innate immune system and by acting as an opsonin. Among the SAA isoforms, mammary associated SAA3 (m-SAA3) is important. The blood concentration of SAA and Hp increases dramatically after LPS infusion, with SAA (acute and middle phase of APR) appearing before Hp (Late phase of APR). The herd level APP might be useful for determining the prevalence of clinical and subclinical infections indicated by the high serum concentration of selected APP and by serving as the prognostic tool. APPs, used as markers of animal health may possibly be influenced by environmental factors, handling procedures and other types of stress in the absence of disease.

REFERENCES


  1. Abernethy TJ and Avery OT (1941) The occurrence during acute infections of a protein not normally present in the blood. J Exp Med 73:173-182

  2. Badolato R., Wang JM, Murphy WJ, Lloyd AR, Michiel DF and Bausserman LL (1994). Serum amyloid-As a chemoattractant- induction of migration, adhesion and tissue infiltration of monocytes and polymorphonuclear leukocytes J Exp Med 180:203-209

  3. Bannerman D, Kauf A, Paape M, Springer H and Goff J (2008) Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection. J Dairy Sci 91:2225-2235

  4. Bannerman DD, Paape MJ, Hare WR and Sohn EJ (2003) Increased levels of LPS binding protein in bovine blood and milk following bacterial lipopolysaccharide challenge. J Dairy Sci 86:3128-3137

  5. Bansal BK and Gupta DK (2009) Economic analysis of bovine mastitis in India and Punjab-A review. Indian J Dairy Sci 67:337-345

  6. Berczi I (1998) Neurohormonal host defense in endotoxin shock. Ann N Y Acad Sci. 840: 787-802. 

  7. Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP and Cipollo JF (2009) Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood 113:2578-2586

  8. Ceciliani F, Ceron JJ, Eckersall PD and Sauerwein H (2012) Acute phase proteins in ruminants. J Proteomics 75:4207-4231

  9. Ceciliani F, Pocacqua V, Miranda-Ribera A, Bronzo V, Lecchi C and Sartorelli P (2007) Alpha 1-acid glycoprotein modulates apoptosis in bovine monocytes. Vet Immunol Immunopathol 116:145–152

  10. Ceciliani F, Pocacqua V, Provasi E, Comunian C, Bertolini A and Bronzo V (2005) Identification of the bovine alpha 1-    acid glycoprotein in colostrum and milk. Vet Res 36: 735–746

  11. Cole DJ, Roussel AJ and Whitney MS (1997) Interpreting a bovine CBC: Evaluating the leukon and acute-phase proteins. Vet Med 92: 470

  12. Eckersall PD and Conner JG (1990) Plasma haptoglobin in cattle (Bos taurus) exists as polymers in association with albumin. Comp Biochem Physiol 96B:309-311

  13. Eckersall PD, Young FJ, McComb C, Hogarth CJ, Safi S and Weber A (2001) Acute phase proteins in serum and milk from dairy cows with clinical mastitis Vet Rec 148:35-41

  14. Fan MH, Klein RD, Steinstraesser L, Merry AC, Nemzek JA and Remick DG (2002) An essential role for lipopolysaccharide-    binding protein in pulmonary innate immune responses. Shock 18:248-254

  15. Flower DR, North ACT and Sansom CE (2000) The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta Protein Struct Mol Enzymol 1482:9-24

  16. Gabay C and Kushner I (1999) Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340: 448-454

  17. Gerardi G, Bernardini D, Elia CA, Ferrari V, Iob L and Segato S (2009) Use of serum amyloid A and milk amyloid A in the diagnosis of subclinical mastitis in dairy cows. J Dairy Res 76:411-417

  18. Gronlund U, Hulten C, Eckersall PD, Hogarth C and Waller KP (2003) Haptoglobin and serum amyloid A in milk and serum during acute and chronic experimentally induced Staphylococcus aureus mastitis. J Dairy Res 70:379-386

  19. Gruys E, Obwolo MJ and Toussaint MJM (1994) Diagnostic significance of the major acute phase proteins in veterinary clinical chemistry: a review. Vet Bull 64:1009-1018

  20. Heinrich PC, Castell JC and Andus T (1990) Interleukin-6 and the acute phase response. Biochem J 265:621-636

  21. Hirvonen J, Pyorala S and Jousimies-Somer H (1996) Acute phase response in heifers with experimentally induced mastitis. J Dairy Res 63:351-360

  22. Hiss S, Mielenz M, Bruckmaier R and Sauerwein H (2004) Haptoglobin concentrations in blood and milk after endotoxin challenge and quantification of mammary Hp mRNA expression. J Dairy Sci 87:3778-3784

  23. Horadagoda NU, Eckersall PD, Andrew L, Gallay P, Heumann D and Gibbs HA (1994) Identification of lipopolysaccharide binding protein-like activity in bovine serum. Biochem Soc Trans 22:329S

  24. Horadagoda NU, Knox KMG, Gibbs HA, Reid SWJ, Horadagoda A and Edwards SER (1999) Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Vet Rec 144:437-441

  25. Israili ZH, Dayton PG (2001) Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev 33:161-235

  26. Jensen LE and Whitehead AS (1998) Regulation of serum amyloid A protein expression during the acute phase response. Biochem J 334:489-503

  27. Kauf A, Rosenbusch R, Paape M and Bannerman D (2007) Innate immune response to intramammary Mycoplasma bovis infection. J Dairy Sci 90:3336-3348

  28. Khemlani LS, Yang Z and Bochsler PN (1994). Identification and Characterization of a Bovine Lipopolysaccharide-    binding Protein. Journal of Leukocyte Biology 56:784-791

  29. Kumar P, Sharma A, Sindhu N and Deora A (2014a) Acute phase proteins as indicators of inflammation in streptococcal and staphylococcal mastitis in buffaloes. Haryana Vet 53:46-49

  30. Kumar P, Sharma A, Sindhu N and Deora A (2014b) Kinetics of acute phase proteins in streptococcal and staphylococcal mastitis in cows. Indian J Comp Microbiol Infect Dis 35:13-17

  31. Lamping N, Hoess A, Yu B, Park TC, Kirschning CJ, Pfeil D, Reuter D, Wright SD, Herrmann F and Schumann RR (1996). Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-    binding protein on binding and transfer of LPS and subsequent immune cell activation. J Immunol S 231-240

  32. Larson MA, Weber A, Weber AT and McDonald TL (2005) Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide. Vet Immunol Immunopathol 107:255-264

  33. Lehtolainen T, Rontved C and Pyorala S (2004) Serum amyloid A and TNFá in serum and milk during experimental endotoxin mastitis. Vet Res 35:651-659

  34. Lim SK, Kim H, Lim SK, Bin Ali A, Lim YK, Wang Y, Chong SM, Costantini F and Baumman H (1998) Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 92: 1870-1877 

  35. McDonald TL, Larson MA, Mack DR and Weber A (2001) Elevated extrahepatic expression and secretion of mammary associated serum amyloid A3 (M-SAA3) into colostrum. Veterinary Immunology Immunopathology 83:203–211

  36. Molenaar AJ, Harris D, Rajan GH, Pearson ML, Callaghan MR and Sommer L (2009) The acute-phase protein serum amyloid A3 is expressed in the bovine mammary gland and plays a role in host defence. Biomarkers 14:26-37

  37. Morimatsu M, Syuto B, Shimada N, Fujinaga T, Yamamoto S and Saito M (1991) Isolation and characterization of bovine haptoglobin from acute phase sera. J Biol Chem 266:11833-11837

  38. Moshage H (1997) Cytokines and the hepatic acute phase response. J Pathol 181:257-266

  39. Murata H, Shimada N and Yoshioka M (2004) Current research on acute phase proteins in veterinary diagnosis: An overview. Vet J 168:28-40

  40. Petersen HH, Nielsen JP and Heegaard PMH (2004) Application of acute phase protein measurement in veterinary clinical chemistry. Vet Res 35:163-87

  41. Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM and Haskard DO (2004) Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis-antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo and after cardiopulmonary bypass surgery. Circ Res 94:119-126

  42. Rahman M, Lecchi C, Avallone G, Roccabianca P, Sartorelli P and Ceciliani F (2010) Lipopolysaccharide-binding protein: local expression in bovine extrahepatic tissues. Vet Immunol Immunopathol 137:28-35

  43. Rinaldi M, Ceciliani F, Lecchi C, Moroni P and Bannerman DD (2008) Differential effects of alpha 1-acid glycoprotein on bovine neutrophil respiratory burst activity and IL-8 production. Vet Immunol Immunopathol 126:199-210

  44. Rinaldi M, Li RW, Bannerman DD, Daniels KM, Evock-Clover C and Silva MV (2010) A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. coli mastitis. Funct Integr Genomics 10:21-38

  45. Rother RP, Bell L, Hillmen P and Gladwin M.T (2005) The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin — a novel mechanism of human disease. JAMA 293:1653-1662

  46. Saeed SA, Ahmad N and Ahmed S (2007) Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding. Biochem Biophys Res Commun 353:915-920

  47. Salonen M, Hirvonen J, Pyorala S, Sankari S and Sandholm M (1996) Quantitative determination of bovine serum haptoglobin in experimentally induced Escherichia-coli mastitis. Res Vet Sci 60:88-91

  48. Schaer CA, Schoedon G, Imhof A, Kurrer MO and Schaer DJ (2006) Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. Circ Res 99:943-950

  49. Schroder NW and Schumann RR (2005) Non-LPS targets and actions of LPS binding protein (LBP). J Endotoxin Res 11: 237-242 

  50. Schroedl W, Fuerll B, Reinhold P, Krueger M and Schuett C (2001) A novel acute phase marker in cattle: lipopolysaccharide binding protein (LBP). J Endotoxin Res 7:49-52

  51. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD and Mathison JC (1990) Structure and function of lipopolysaccharide binding-protein. Science 249:1429-1431

  52. Sheldon IM, Noakes DE, Rycroft A and Dobson H (2001) Acute phase protein responses to uterine bacterial contamination in cattle after calving. Vet Rec 148:172-175

  53. Skinner JG, Brown RAL and Roberts L (1991) Bovine haptoglobin response in clinically defined field conditions. Vet Rec 128:147-149

  54. Sunagar R, Deore SN, Deshpande PV, Rizwan A, Sannejal AD, Sundareshan S, Rawool DB, Barbuddhe SB, Jhala, MK, Bannalikar AS, Mugalikar DM, Kumari VJ, Dhanalakshmi K, Reddy YN, Rao PP, Babra C, Tiwari JG, Mukkur TK, Castantino P, Wetherall JD, Isloor S and Hegde NR (2013) Differentiation of Staphylococcus aureus and Staphylococcus epidermidis by PCR for the fibrinogen binding protein gene. J Dairy Sci 96:2857-2865

  55. Suojala L, Orro T, Jarvinen H, Saatsi J and Pyorala S (2008) Acute phase response in two consecutive experimentally induced E. coli intramammary infections in dairy cows. Acta. Vet Scand 50:18

  56. Thulasiraman P, Mukherjee J, Banerjee D, Guru DV, Das P, Ghosh PR and Das PK (2013) Acute Phase Protein - a Potent Biomarker for Mastitis. Vetscan 7:6-14

  57. Uhlar CM and Whitehead AS (1999) Serum amyloid A, the major vertebrate acute-phase reactant. European Journal of Biochemistry. 265:501-523

  58. Vels L, Rontved CM, Bjerring M and Ingvartsen K L (2009) Cytokine and acute phase protein gene expression in repeated liver biopsies of dairy cows a lipopolysaccharide-induced mastitis. Journal of Dairy Science. 92: 922-934 

  59. Weber A, Weber AT, McDonald TL and Larson MA (2006) Staphylococcus aureus lipoteichoic acid induces differential expression of bovine serum amyloid A3 (SAA3) by mammary epithelial cells: implications for early diagnosis of mastitis. Vet Immunol Immunopathol 109:79-83

  60. Whelehan CJ, Meade KG, Eckersall P, Young FJ and O’Farrelly C (2011) Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression. Vet Immunol Immunopathol 140:181-189

  61. Wright SD, Tobias PS, Ulevitch RJ and Ramos RA (1989) Lipopolysaccharide (LPS) binding-protein opsonizes LPS-    bearing particles for recognition by a novel receptor on macrophages. J Exp Med 170:1231-1241

  62. Yoshioka M, Ito T, Miyazaki S and Nakajima Y (1998) The release of tumor necrosis factor-á, interleukin-1, interleukin-    6 and prostaglandin E2 in bovine Kupffer cells stimulated with bacterial lipopolysaccharide. Vet Immunol Immunopathol 66:301-307

  63. Yoshioka M, Watanabe A, Shimada N, Murata H, Yokomizo Y and Nakajima Y (2002) Regulation of haptoglobin secretion by recombinant bovine cytokines in primary cultured bovine hepatocytes. Domest Anim Endocrinol 23:425-433

  64. Zeng R, Bequette B, Vinyard B and Bannerman D (2009) Determination of milk and blood concentrations of lipopolysaccharide-binding protein in cows with naturally acquired subclinical and clinical mastitis. J Dairy Sci 92:980-989

     
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