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Reviewer Article

Agricultural Reviews, volume 42 issue 4 (december 2021) : 359-370

Comparative Study of the Distribution and Localization of Neuroglobin Expression in the Mammalian Brain: A Literature Review

James Blackar Mawolo, Caselia Akiti
1College of Life Science and Technology, Gansu Agricultural University, Lanzhou City, Gansu Province, People’s Republic of China. 
Cite article:- Mawolo Blackar James, Akiti Caselia (2021). Comparative Study of the Distribution and Localization of Neuroglobin Expression in the Mammalian Brain: A Literature Review. Agricultural Reviews. 42(4): 359-370. doi: 10.18805/ag.R-153.

ABSTRACT

Neuroglobin (Ngb) was recently identified as a member of the vertebrate hemoglobin family. Several studies have been conducted on Ngb in mammals, but none have compared its expression and localization among different mammals. This review compared the distribution and localization of Ngb expression and explained the different functions of Ngb in the brains of mammals. Intel’s integrated performance primitive (IPP) analysis was employed to obtain the expression levels in each region of the mammalian brain. Ngb is widely expressed in the adult yak brain and distributed in different areas, similar to its expression in cattle. The relative expression of the Ngb gene in the cerebral cortex (262.69 ± 9.19) was significantly higher than that in the cerebellar cortex (137.00 ± 7.29), hippocampus (1.00 ± 0.22), medulla oblongata (3.43 ± 0.76), striatum (7.65 ± 0.61) and olfactory bulb (2.14 ± 1.22). Findings in the rat brain showed low Ngb protein expression. The mouse brain showed Ngb over expression in a transgenic variant (Ngb-Tg), while in the human brain, the level of Ngb was higher in the hypothalamus, amygdala and pontine tegmental nuclei than in other parts of the brain. The expression levels, distribution and localization of Ngb differ across the brains of different mammals, so it is appropriate to explore the precise distribution and localization of Ngb before comparison or analysis in these mammals.

REFERENCES

  1. Adelman, D.M., Gertsenstein, M., Nagy, A., Simon, M.C. and Maltepe, E., (2000). Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev. 14: 3191-3203. doi:10.1101/qad.853700
  2. Avivi, A., Gerlach, F. and Joel, A. (2010). Neuroglobin, Cytoglobin and Myoglobin contribution to hypoxia adaptation of the subterranean mole rat Spalax [J]. Proc. Natl. Acad. Sci. USA, 107(50): 21570-21575.doi: 10.1073/pnas.1015379107.
  3. Bederson, J.B., Germano, I.M. and Guarino, L. (1995). Cortical blood flow and cerebral perfusion pressure in a new non craniotomy model of subarachnoid hemorrhage in the rat. Stroke J Cereb Circ 26(6): 1086-1091 discussion 1091-1082 (59) doi:10.1161/01.str.26.6.1086.
  4. Burmester, T., Weich, B., Reinhardt S. and Hankeln T. (2000). A vertebrate globin expressed in the brain. Nature. 407: 520-523. doi:10.1038/35035093.
  5. Capece, L., Marti, M.A., Bidon-Chanal, A., Nadra, A., Luque, F.J. and Estrin, D.A. (2009). High pressure reveals structural determinants for globin hexa-coordination: neuroglobin and myoglobin cases. Proteins 75(4): 885-894. doi:10.1002/prot.22297.
  6. Chen, L.M., Xiong, Y.S., Kong, F.L., Qu, M., Wang, Q., Chen, X.Q., et al. (2012). Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J. Neurochem 120(1): 157-164. doi:10.1111/j.1471-4159.2011.07275.x.
  7. Chuang, P.Y., Conley, Y.P., Poloyac, S.M., Okonkwo, D.O., Ren, D., Sherwood P.R., et al. (2010). Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. J. Neurotrauma. 27(6): 999-1006 (45). doi:10.1089/neu.2009.1129.
  8. Dewilde, S., (2001). Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J. Biol. Chem. 276: 38949-38955. doi:10.1074/jbc.M106438200.
  9. DellaValle, B., Hempel, C., Kurtzhals, J.A. and Penkowa, M. (2010). In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria and autoimmune encephalitis. Glia. 58(10): 1220-1227. (60)doi: 10.1002/glia.21002.
  10. Duong, T.T., Witting, P.K., Antao, S.T., Parry, S.N., Kennerson, M., Lai, B., et al., (2009). Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia reoxygenation-injury. J. Neurochem 108(5): 1143-1154. doi:10. 1111/j.1471-4159.2008.05846.x.
  11. Fago, A., Hundahl, C., Dewilde, S., Gilany, K., Moens, L. and Weber, R.E. (2004). Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. J. Biological Chem. 279(43): 44417-44426. doi:10.1074/jbc.M407126200.
  12. Guo, Z.D., Sun, X.C. and Zhang, J.H. (2011). Mechanisms of early brain injury after SAH: matrix metalloproteinase 9. Acta Neurochir Supplement 110(Pt 1), 63-65. doi:10.1007/    978-3-7091-0353-1_11 (58).
  13. Greenberg, D.A., Jin, K., Khan, A.A. (2001). Neuroglobin: An endogenous neuroprotectant. Curr. Opin. Pharmacol. 8: 20-24. 23. 
  14. Hundahl, C.A., Luuk, H., Ilmjarv, S., Falktoft, B., Raida, Z., Vikesaa, J., et al. (2011). Neuroglobin-deficiency exacerbates Hif1A and c-FOS response but does not affect neuronal survival during severe hypoxia in vivo. PLoS One. 6(12): e28160. doi: 10. 1371/journal.pone.0028160.
  15. Hundahl, C.A., Hay-Schmidt A., Kelsen J. (2013). Neuroglobin and Cytoglobin expression in the human brain. Brain Struct Funct. 218, 603-609. doi:10.1007/s00429-012-0480-8.
  16. Hundahl, C.A., Allen, G.C., Nyengaard, J.R., Dewilde, S., Carter, B.D., Kelsen, J. and Hay-Schmidt, A. (2008a) Neuroglobin in the rat brain:localization. Neuroendocrinology. 88(3): 173-182. (54)doi: 10.1159/000129698.
  17. Hundahl, C.A., Kelsen, J., Dewilde, S. and Hay-Schmidt. A. (2008b). Neuroglobin in the rat brain (II): Co-localization with neurotransmitters. Neuroendocrinology. 88(3): 183-198. (55) doi: 10.1159/000135617.
  18. Hundahl, C.A., Allen, G.C., Hannibal, J., Kjaer, K., Rehfeld, J.F., Dewilde, S., et al. (2010a). Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain. Brain Res. 1331: 58-73. (56). doi:10.1016/j.brainres.2010.03.056.
  19. Hundahl, C.A., Hannibal, J., Fahrenkrug, J., Dewilde, S. and Hay-Schmidt, A. (2010b). Neuroglobin expression in the rat suprachiasmatic nucleus: colocalization, innervation and response to light. J. Comp Neurol. 518(9): 1556-1569(57). doi: 10.1002/cne.22290. 
  20. Hundahl, C.A., Fahrenkrug, J., Hay-Schmidt, A., George, B., Faltoft, B. and Hannibal, J. (2012a). Circadian behaviour in neuroglobin deficient mice. PLoS ONE. 7(4): e34462 (62) doi:10.1371/journal.pone.0034462.
  21. Jain, K.K., (2008). Neuroprotection in traumatic brain injury. Drug Discov. Today. 13(23-24): 1082-1089 (47) doi:10.3389/fneur.2017.00354.
  22. Jin, K., Mao, X.O., Xie, L., John, V. and Greenberg, D.A. (2011). Pharmacological induction of neuroglobin expression. Pharmacology. 87(1-2): 81-84 (52). doi: 10.1159/000322998.
  23. Jin, K., Mao, X.O., Xie, L., Khan, A.A. and Greenberg, D.A. (2008). Neuroglobin protects against nitric oxide toxicity. Neurosci. Lett. 430(2): 135-137 (50). doi:10.1016/j.neulet.2007.10.031.
  24. Jin, K., Mao, Y., Mao X, Xie L, Greenberg, D.A. (2010). Neuroglobin expression in ischemic stroke. Stroke. 41(3): 557-559. doi:10.1161/STROKEAHA.109.567149.
  25. Kriegl, J.M., Bhattacharyya, A.J., Nienhaus, K., Deng, P., Minkow, O. and Nienhaus, G.U. (2002). Ligand binding and protein dynamics in neuroglobin. Proc Natl Acad Sci USA 99(12): 7992-7997. doi:10.1073/pnas.082244399.
  26. Khan, A.A,. Mao, X.O., Banwait, S., DerMardirossian, C.M., Bokoch, G.M., Jin, K., et al. (2008). Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J. 22(6): 1737-1747. doi:10.1096/fj.07-1007844/jbc.M305519200.
  27. Laufs, T., Wystub, S. and Reuss, S. (2004). Neurons specific expression of Neuroglobin in mammals [J]. Neurosci. Lett. 362(2): 83-86. 10.1016/j.neulet.2004.02.072.
  28. Li, R.C., Pouranfar, F., Lee, S.K., Morris, M.W., Wang, Y. and Gozal, D. (2008). Neuroglobin protects PC12 cells against beta-amyloid-induced cell injury. Neurobiol. Ag. 29(12): 1815-1822. doi:10.1016/j. neurobiolaging.2007.05.001.
  29. Liu, J., Yu, Z., Guo, S., Lee, S.R., Xing, C., Zhang, C., et al. (2009). Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J. Neurosci. Res. 87(1):164-170 (49).
  30. Liang, C., Xia, L., Ning-ning, S.,and Xiao-hua, D. (2013). Distribution of neuroglobin in different tissues and cells of the adult yak. Acta Anatomica Sinica. 44-1. doi:10.13207/j.cnki.jnwafu. 2015.06.012.
  31. Lin, X., Li, M., Hu, Y.Z., Han, Z.T., Zhang, H.H., Shang, A.J., et al. (2010). An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury. Zhongguo Ying Yong Sheng Li Xue Za Zhi 26(1): 39-44 (44). doi:10.3969/j.issn.1673.2012.25.006.
  32. Ni, B., Rush S., Gurd J.W. and Brown I.R. (1992). Molecular cloning of calmodulin mRNA species which are preferentially expressed in neurons in the rat brain. Molecular Brain Research. 13: 7-17. doi:10.1016/0169-328x(92)90039-e.
  33. Nornes, H. (1973). The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. J. Neurosurg. 39(2): 226-234. doi:10.3171/jns.1973.39.2.0226.
  34. Pesce, A., Bolognesi, M., Bocedi, A., Ascenzi, P., Dewilde, S., Moens L., Hankeln T. and Brumster, T. (2002). Neuroglobin and cytoglobin. EMBO Reports. 1146-1151. CrossRef PubMed Web of Science Google Scholar.
  35. Pesce, A., Dewilde, S., Nardini, M., Moens, L., Ascenzi, P., Hankeln, T., et al. (2003). Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure 11(9): 1087-1095. doi: 10.1016/s0969-2126(03)00166-7.
  36. Reuss, S., Saaler-Reinhardt, S., Weich, B., Wystub, S., Reuss, M.H., Burmester, T. and Hankeln, T. (2002). Expression analysis of neuroglobin mRNA in rodent tissues. Neuroscience. 115: 645-656. CrossRef PubMed Web of Science Google Scholar.
  37. Schubert, G.A., Seiz, M., Hegewald, A.A., Manville, J. and Thome C. (2011). Hypoperfusion in the acute phase of subarachnoid hemorrhage. Acta Neurochir. Supplement 110(Pt 1): 35-38. doi: 10.1007/978-3-7091-0353-1_6.
  38. Shang, A., Liu, K., Wang, H., Wang, J., Hang, X., Yang, Y., et al. (2012). Neuroprotective effects of neuroglobin after mechanical injury. Neurol Sci. 33(3): 551-558 (46). doi:10.1007/s10072-011-0772-4. 
  39. Shang, A.J., Zhou, D.B. and Zhang, Ch.G. (2006). Cellular localization of neuroglobin expression in rat brain. [J]. Chinese Journal of Neuro Medicine. 5(9): 891-893. doi:10.1007/s10571-013-0008-7.
  40. Shang, A.J., Zhou, D.B. and Meng, X.H. (2006). Distribution of neuroglobin in the spinal cord of adult yak [J]. Acta Anatomica Sinica. 37(5): 492-494. doi:10.3969/j.issn.0529- 1356.2013.01.01.013.
  41. Sun, Q., Dai, Y., Zhang, X., Hu, Y.C., Zhang, D., Li, W., et al. (2013). Expression and cell distribution of myeloid differentiation primary response protein 88 in the cerebral cortex following experimental subarachnoid hemorrhage in rats: a pilot study. Brain Res. 1520, 134-144. doi:10.1016/j.brainres.2013.05.010.
  42. Sun, Y., Jin, K., Peel, A., Mao, X.O., Xie, L., Greenberg, D.A. (2003). Neuroglobin protects the brain from experimental stroke in vivo. Proc. Natl. Acad. Sci. USA 100: 3497-3500.
  43. Sun, Y., Jin, K.,and Mao, X.O. (2001). Neuroglobin is regulated by and protects neurons from hypoxic-ischemic-injury. Proc Natl Acad Sci USA. 98(26): 15306-15311. doi:10.1073/pnas.251466698.
  44. Sun, Y., Jin, K., Mao, X.O., Zhu Y. and Greenberg D.A. (2001). Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc. Natl. Acad. Sci. USA. 98: 15306–15311. doi:10.1073/pnas.251466698.
  45. Sun, Y., (2003) Neuroglobin protects the brain from experimental stroke in vivo. Proc. Natl. Acad. Sci. USA 100: 3497-3500. doi:10.1073/pnas.0637726100.
  46. Sun, Y., Jin, K., Peel, A., Mao, X.O., Xie, L. and Greenberg, D.A. (2003). Neuroglobin protects the brain from an experimental stroke in vivo. Proc Natl Acad Sci USA. 100(6): 3497-3500 (43). doi:10.1073/pnas.0637726100.
  47. Tiso, M., Tejero, J., Basu, S., Azarov, I., Wang, X., Simplaceanu, V., et al. (2011) Human neuroglobin functions as a redox- regulated nitrite reductase. J. Biological Chem. 286(20): 18277-18289. doi:10.1074/jbc.M110.159541.
  48. Tong-fang, L., Xia L., Xue-jing S. and Xiao-hua, D. (2015). Distribution of Neuroglobin in the brain of adult yak. Journal of Northwest AandF University (Nat. Sci. Ed.) 05,11 15-03. doi:10.3969/j.issn.0529-1356.2013.01.01.013.
  49. Wakasugi K, Nakano T. and Morishima I. (2003). Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. J. Biological Chem. 278(38): 36505-36512. doi:10.1074/jbc.M305519200.
  50. Wang, H.Y., Deng, M.Y. and Wang, J. (2004). Expression of neuroglobin gene in brain and different cellular tissues. Acad. J. PLA Postgraduate Medical Sch. 25(4): 318-320. doi: 10.1007/s10571-013-0008-7.
  51. Wei, X., Yu, Z., Cho, K.S., Chen, H., Malik, M.T., Chen, X., et al. (2011). Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am. J. Pathol. 179(6): 2788-2797 (51) doi: 10.1002/    jnr.21826.
  52. Wei-De L., Qing, S., Xiang S., ZhangX., Song L., Wei L., et al. (2013). Expression and Cell Distribution of Neuroglobin in the Brain Tissue After Experimental Subarachnoid Hemorrhage in Rats: A Pilot Study. Cell. Mol. Neurobiol. doi:10.1007/s10571-013-0008-7.
  53. Xin, L.,Min, L., Aijia, S., Yazhuo, H., Xiao, Y., et al. (2012). Neuroglobin expression in rats after traumatic brain injury. Neural Regen Res. 7(25): 1960-1966 (53) doi: 10.3969/j.issn.1673-5374.2012.25.006.
  54. Yu, Z., Liu, N., Li, Y., Xu, J. and Wang, X. (2013). Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons. Neurobiol Dis. doi:10.1016/j.nbd.2013.04.015.
  55. Zhao, S., Yu Z., Zhao, G., Xing C., Hayakawa K., Whalen M.J.,and Lok, J.M. (2012). Lo mice. Neuroscience. 13: 67. doi:10.1371/journal.pone.0076565.
  56. Zhang, K.Y., Niu, S.Q. and Chen, Y. (2008). The research of human nucleus orientation. Journal of Jilin Medical College. 29(3): 157-159. doi:10.4161/cam.27761.
  57. Zivin, J.A. (2008). Factors determining the therapeutic window for stroke [J]. Neurology. 50(3): 599-603. doi:10.1212/wnl.50.3.599
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