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volume 32 issue 3 (september 2011) : 228 - 232

BOVINE FACTOR XI DEFICIENCY: A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW

V
Vijay Kumar*
C
Chandrashekhar S. Patil
R
Raghvendra Kumar Sharma
1Dairy Cattle Breeding Division National Dairy Research Institute, Karnal-132001, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Kumar* Vijay, Patil S. Chandrashekhar, Sharma Kumar Raghvendra (2025). BOVINE FACTOR XI DEFICIENCY: A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW. Agricultural Reviews. 32(3): 228 - 232. doi: .

ABSTRACT

Bovine Factor XI Deficiency is one of the most important recessive hereditary disorder of Holstein cattle. It is characterized by prolonged bleeding, anemia, greater prevalence of repeat breeding, or even lower resistance to pneumonia, mastitis and metritis resulting in reduced reproductive performance and increased susceptibility to disease. The molecular basis of this coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene. This disorder has an adverse impact on reproductive traits and udder health in cattle. The only way to avoid economic losses is through an early detection of carriers.  The use of PCR based molecular technologies promises quick detection of carriers enables their culling and thus controlling and preventing the spread of FXI deficiency in the population.

REFERENCES

  1. Azad MS (2010). Detection of coagulation factor XI gene deficiency in dairy cattle. M.V.Sc. Thesis, National Dairy Research Institute, Karnal.
  2. Brush PJ, Anderson PH and Gunning RF (1987). Identification of factor XI deficiency in Holstein Friesian cattle in Britain. Vet Rec 121: 14–17.
  3. Gentry PA and Black WD (1980). Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle. J Dairy Sci 63: 616–620.
  4. Gentry PA, Crane S and Lotz F (1975). Factor XI (plasma thromboplastin antecedent) deficiency in cattle.Can Vet J 16: 160–163.
  5. Gentry PA and Downie HG (1977). Blood coagulation In: Swenson MJ ed. Duke’s physiology of domestic animals, 9th ed. Cornell University Press, Ithaca, NY.
  6. Gentry PA, Overton KM and Robinson JL (1996). Bovine factor XI deficiency. Illinois Dairy Report: 32–35.
  7. Gentry PA and Ross ML (1986). Failure of routine coagulation screening tests to detect heterozygous state of bovine factor XI deficiency. Vet Clin Pathol 15: 12–16.
  8. Gentry PA and Ross ML (1994). Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Can J Vet Res 58: 242–247.
  9. Ghanem ME, Nishibori M, Nakao T, Nakatani K and Akita M (2005). Factor XI mutation in a Holstein cow with repeat breeding in Japan. J Vet Med Sci 67: 713–715.
  10. Kehrli ME, Ackermann MR, Shuster DE, Maaten VD, Schmalstieg FC, Anderson DC and Hughes BJ (1990). Animal model of human disease. Bovine leukocyte adhesion deficiency. â2 integrin deficiency in young Holstein cattle. Am J Pathol 140: 1489-1492.
  11. Kociba GJ, Ratnoff OD, Loeb WF, Wall RL and Heider LE (1969). Bovine thromboplastin antecedent (factor XI) deficiency. J Lab Clin Med 74: 37–41.
  12. Kumar V and Sharma A (2009). Bovine Leukocyte Adhesion Deficiency Syndrome (BLAD): A recessive disorder in Holstein Freisian cattle-A Review. Agric Rev 30: 293-300
  13. Kumar V, Yathish HM and Sharma A (2011). Single Nucleotide Polymorphism (SNP) identification of CD18 gene in Indian Holstein crossbred cattle. Indian Vet J 88: 40-41.
  14. Liptrap RM, Gentry PA, Ross ML and Cummings E (1995). Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency. Vet Res Commun 19: 463–471.
  15. Mahdipour M, Sharma A, Dubey PP, Singh A, Tantia MS, Mishra B, Kumar V and Joshi BK (2010). PCR based identification of bovine leukocyte adhesion deficiency syndrome (BLAD) carriers in Karan Fries bulls Indian J Anim Sci 80: 433-435.
  16. Mahdipour M, Sharma A, Dubey PP, Kumar V, Mishra B and. Joshi BK (2010). Identification of Complex Vertebral Malformation using Polymerase chain reaction primer introduced restriction analysis in Karan Fries bulls. J Current Trend Biotech Pharm 4: 850-854
  17. Marron BM, Robinson JL, Gentry PA and Beever JE (2004). Identification of a mutation associated with factor XI deficiency in Holstein cattle. Anim Genet 35: 454–456.
  18. Mukhopadhyaya PN, Jha M, Muraleedharan P, Gupta RR, Rathod RN, Mehta HH and Khoda VK (2006). Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency. Genet Mol Res 5: 323–332.
  19. Patel RK, Soni KJ, Chauhan JB, Singh KM, Krothapalli RS and Rao S (2007). Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis. Genet Mol Biology 30: 580-583.
  20. Revell S. 2001. Complex vertebral malformation in a Holstein calf in the UK. Vet Res 149: 659– 660.
  21. Robinson JL, Popp RG, Shanks RD, Oosterhof A and Veerkamp JH (1993) Testing for deficiency of uridine monophosphate synthase among Holstein-Frisian cattle of North America and Europe. Livest Prod Sci 36: 287-298.
  22. Rosenthal RL, Dreskin OH and Rosenthal N (1953). New hemophilia-like disease caused by deficiency of a third plasma thromboplastin factor. Proc Soc Exp Biol Med 82: 171–174.
  23. Yathish HM, Sharma A, Kumar V, Jain A, Chakraborty D, Singh A, Tantia MS and Joshi BK (2010). Genetic polymorphism of CD18 gene in. Karan fries young bulls using PCR-RFLP analysis. J Current Trend Biotech Pharm 4: 899-906
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    volume 32 issue 3 (september 2011) : 228 - 232

    BOVINE FACTOR XI DEFICIENCY: A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW

    V
    Vijay Kumar*
    C
    Chandrashekhar S. Patil
    R
    Raghvendra Kumar Sharma
    1Dairy Cattle Breeding Division National Dairy Research Institute, Karnal-132001, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Kumar* Vijay, Patil S. Chandrashekhar, Sharma Kumar Raghvendra (2025). BOVINE FACTOR XI DEFICIENCY: A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW. Agricultural Reviews. 32(3): 228 - 232. doi: .

    ABSTRACT

    Bovine Factor XI Deficiency is one of the most important recessive hereditary disorder of Holstein cattle. It is characterized by prolonged bleeding, anemia, greater prevalence of repeat breeding, or even lower resistance to pneumonia, mastitis and metritis resulting in reduced reproductive performance and increased susceptibility to disease. The molecular basis of this coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene. This disorder has an adverse impact on reproductive traits and udder health in cattle. The only way to avoid economic losses is through an early detection of carriers.  The use of PCR based molecular technologies promises quick detection of carriers enables their culling and thus controlling and preventing the spread of FXI deficiency in the population.

    REFERENCES

    1. Azad MS (2010). Detection of coagulation factor XI gene deficiency in dairy cattle. M.V.Sc. Thesis, National Dairy Research Institute, Karnal.
    2. Brush PJ, Anderson PH and Gunning RF (1987). Identification of factor XI deficiency in Holstein Friesian cattle in Britain. Vet Rec 121: 14–17.
    3. Gentry PA and Black WD (1980). Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle. J Dairy Sci 63: 616–620.
    4. Gentry PA, Crane S and Lotz F (1975). Factor XI (plasma thromboplastin antecedent) deficiency in cattle.Can Vet J 16: 160–163.
    5. Gentry PA and Downie HG (1977). Blood coagulation In: Swenson MJ ed. Duke’s physiology of domestic animals, 9th ed. Cornell University Press, Ithaca, NY.
    6. Gentry PA, Overton KM and Robinson JL (1996). Bovine factor XI deficiency. Illinois Dairy Report: 32–35.
    7. Gentry PA and Ross ML (1986). Failure of routine coagulation screening tests to detect heterozygous state of bovine factor XI deficiency. Vet Clin Pathol 15: 12–16.
    8. Gentry PA and Ross ML (1994). Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Can J Vet Res 58: 242–247.
    9. Ghanem ME, Nishibori M, Nakao T, Nakatani K and Akita M (2005). Factor XI mutation in a Holstein cow with repeat breeding in Japan. J Vet Med Sci 67: 713–715.
    10. Kehrli ME, Ackermann MR, Shuster DE, Maaten VD, Schmalstieg FC, Anderson DC and Hughes BJ (1990). Animal model of human disease. Bovine leukocyte adhesion deficiency. â2 integrin deficiency in young Holstein cattle. Am J Pathol 140: 1489-1492.
    11. Kociba GJ, Ratnoff OD, Loeb WF, Wall RL and Heider LE (1969). Bovine thromboplastin antecedent (factor XI) deficiency. J Lab Clin Med 74: 37–41.
    12. Kumar V and Sharma A (2009). Bovine Leukocyte Adhesion Deficiency Syndrome (BLAD): A recessive disorder in Holstein Freisian cattle-A Review. Agric Rev 30: 293-300
    13. Kumar V, Yathish HM and Sharma A (2011). Single Nucleotide Polymorphism (SNP) identification of CD18 gene in Indian Holstein crossbred cattle. Indian Vet J 88: 40-41.
    14. Liptrap RM, Gentry PA, Ross ML and Cummings E (1995). Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency. Vet Res Commun 19: 463–471.
    15. Mahdipour M, Sharma A, Dubey PP, Singh A, Tantia MS, Mishra B, Kumar V and Joshi BK (2010). PCR based identification of bovine leukocyte adhesion deficiency syndrome (BLAD) carriers in Karan Fries bulls Indian J Anim Sci 80: 433-435.
    16. Mahdipour M, Sharma A, Dubey PP, Kumar V, Mishra B and. Joshi BK (2010). Identification of Complex Vertebral Malformation using Polymerase chain reaction primer introduced restriction analysis in Karan Fries bulls. J Current Trend Biotech Pharm 4: 850-854
    17. Marron BM, Robinson JL, Gentry PA and Beever JE (2004). Identification of a mutation associated with factor XI deficiency in Holstein cattle. Anim Genet 35: 454–456.
    18. Mukhopadhyaya PN, Jha M, Muraleedharan P, Gupta RR, Rathod RN, Mehta HH and Khoda VK (2006). Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency. Genet Mol Res 5: 323–332.
    19. Patel RK, Soni KJ, Chauhan JB, Singh KM, Krothapalli RS and Rao S (2007). Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis. Genet Mol Biology 30: 580-583.
    20. Revell S. 2001. Complex vertebral malformation in a Holstein calf in the UK. Vet Res 149: 659– 660.
    21. Robinson JL, Popp RG, Shanks RD, Oosterhof A and Veerkamp JH (1993) Testing for deficiency of uridine monophosphate synthase among Holstein-Frisian cattle of North America and Europe. Livest Prod Sci 36: 287-298.
    22. Rosenthal RL, Dreskin OH and Rosenthal N (1953). New hemophilia-like disease caused by deficiency of a third plasma thromboplastin factor. Proc Soc Exp Biol Med 82: 171–174.
    23. Yathish HM, Sharma A, Kumar V, Jain A, Chakraborty D, Singh A, Tantia MS and Joshi BK (2010). Genetic polymorphism of CD18 gene in. Karan fries young bulls using PCR-RFLP analysis. J Current Trend Biotech Pharm 4: 899-906
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