Agricultural Reviews

  • Chief EditorPradeep K. Sharma

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Agricultural Reviews, volume 33 issue 3 (september 2012) : 192 - 201


Madan Mohan Sharma, Roop Narayan Verma, Shazia M Jamal, Amla Batra, D.V.Rao
1Department of Botany, University of Rajasthan, Jaipur, 302 055, India
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Cite article:- Sharma Mohan Madan, Verma Narayan Roop, Jamal M Shazia, Batra Amla, D.V.Rao (2024). AN ANTI-ASTHMATIC PLANT: TYLOPHORA INDICA BURM. F. MERRILL - A REVIEW. Agricultural Reviews. 33(3): 192 - 201. doi: .
India has been known to have rich diversity of plants since time immemorial. There were various ailments cured with the help of plants. This review has been prepared keeping in mind respiratory disease i.e. asthma, it is characterized by reversible airway obstruction, airway hyper responsiveness and airway inflammation. The goal of this article is to increase the awareness about importance of plants in medical field and prepare a list of plants used for treating asthma with special reference to Tylophora indica.
  1. Ali, M. (2008). Pharmacognosy (pharmacognnosy & phytochemistry), CBS Publisher & Distributors, 653 pp.
  2. Ali, M., Ansari S.H. and Qadry. J.S. (1991). Rare phenanthroindolizidine alkaloids and a substituted phenanthrene, tyloindane, from Tylophora indica. J. Nat. Prod. 54 (5):1271-1278.
  3. Anonymous, (1976). The wealth of India. Raw materials. PID and CSIR, New Delhi, 10: 398-399.
  4. Arora, S. and Rawat A.K.S. . (2007). Lysosomal enzyme inhibiting activity of flavones fraction from Tylophora indica leaves in arthritis rats. Pharma. Mag. 3 (12): 225-231.
  5. Aurora Health Care, (2005). Annual Report.
  6. Bone, K. (1996). Clinical applications of ayurvedic and chinese herbs. Warwick, Queensland, Australia: Phytothe.134-136.
  7. Debnath, M., Malik C.P. and Bisen. P.S. (2006). Micropropagation: a tool for the production of high quality plant-based medicines. Curr. Pharma. Biotech. 7(1): 33-49.
  8. Dennis, T.T. and Philip. B. (2005). Thidiazuron induced high-frequency shoot organogenesis from leaf derived callus of a medicinal climber, Tylophora indica (Burm. f.) Merrill. In Vitro Cell. Deve. Biol.–Pl. 41 (2): 124- 128.
  9. Faisal, M. and Anis. M. (2005). An efficient in vitro method for mass propagation of Tylophora indica. Biologia Plantarum 49 (2): 257-260.
  10. Ganguly, T., Badheka L.P. and Sain. K.B. (2001). Immunomodulatory effect of Tylophora indica on Con A induced lympho proliferation. Phytomed. 8(6):431-437.
  11. Ganguly, T. and Sainis. K.B. (2001). Inhibition of cellular immune responces by Tylophora indica in experimental models. Phytomed. 8(5): 348-355.
  12. Gao, W., Lam W. , Zhong S., Conrad K., David C.B. and Cheng. Y.C. (2004). A novel mode of action of tylophorine analogs as anti-tumor compounds. Can. Res. 64: 678-688.
  13. Geetha, V.S., Viswanathan S. and Kameswaran L. (1981). Comparison of total alkaloids of Tylophora indica and disodium cromoglycate on mast cell stabilization. Ind. J. Pharma.13:199-201.
  14. Ghani, A. (2003). Medicinal Plants of Bangladesh. The Asiatic Society of Bangladesh. Dhaka, Bangladesh, 430 pp.
  15. Gopalakrishnan, C., D. Shankaranarayan and Nazimudeen S.K. (1980). Effect of tylophorine, a major alkaloid of Tylophora indica, on immuno-pathological and inflammatory reactions. Ind. J. Med. Res. 71:940-8.
  16. Govindachari, T.R., Pai B.R., Rajappa S. and Viswanathan N. (1959). Chem. Indus. (London) 30:950.
  17. Gujrati, V., Patel N., Rao V.N., Nandakumar K., Gouda T.S., Md. Shalam and Shanta Kumar S.M. (2007). Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats. Ind. J.Pharmacol. 39(1): 43-47.
  18. Gupta, M., Mukhtar H. M. and Ahmad S. (2010). Phyto-pharmacological and plant tissue culture overview of Tylophora indica (Burm f.) Merill. J. Pharma. Sci. Res. 2 (7): 401-411.
  19. Gupta, S., George P. and Gupta V. (1979). Tylophora indica in bronchial asthma double blind study. Ind. J. Med. Res. 69: 981-989.
  20. Haranath, P.S. and Shyamalakumari S. (1975). Experimental study on mode of action of Tylophora asthmatica in bronchial asthma. Ind. J. Med. Res. 63(5): 661-670.
  21. Holly J. M. P., Gunnell D.J. and Davey Smith G. (1999). Growth hormone, IGF-1 and cancer. Less intervention to avoid cancer? More intervention to prevent cancer. J. Endocrinol. 162: 321–330. 
  22. Indian Council of Medical Research. (1955). A review work on Indian medicinal plants (including indigenous drugs etc.). ICMR Spe. Report Ser. 30: 105-119.
  23. Indian Medicinal Plants (1996). A Compendium of 500 species, orient Longman, Madras, 5: 339-341.
  24. Kaushik, A., Gurnani C., Sunder S., Dhingra A. and Chimpa V. (2010). Biochemical assessment of in vitro and in vivo culture of Tylophora indica (Burm. F.) Merr. J. Sci. Enginee. Tech. 6 (II): 1-5.
  25. Khanuja, S.P.S. (2003). Medicinal and Aromatic plants as Bioresource: scope and opportunities, In: Mathur A.K., Dwivedi S., Patra D.D., Bagchi G.D., Sangwan N.S., Sharma A. & Khanuja S.P.S. (Eds). Proceedings of First Interactive MEET on Medicinal & Aromatic Plants, CIMAP, pp 1-7. Army Printing Press, Lucknow.
  26. Kiritikar, K.R. and Basu B.D. (2009). Indian Medicinal Plants. International Book.
  27. Kiritikar K.R., Basu B.D. (1918). Indian Medicinal Plants, International Book Publishers, India, 111, 1630- 1632.
  28. Kumar, S., Kumar R. and Khan A. (2011). Medicinal Plant Resources: Manifestation and prospects of life-sustaining healthcare system. J. Biol. Sci. 4 (1): 19-29.
  29. Lawal, I.O., Uzokwe N.E., Igboanugo A.B.I., Adio A.F. and Awosan E.A. (2010). Ethno medicinal information on collation and identification of some medicinal plants in Research Institutes of South-West Nigeria. Afr. J. Pharma. Pharmacol. 4: 1-7.
  30. Malathi, R. and Gomez M.P. (2007). Hepatoprotective effect of methanolic extracts of Tylophora indica against paracetamol-induced liver damages in rats. J. Pharmacol. Toxicol. 2(8): 737-742.
  31. Meera, R., Devi P., Muthumani P. B., Kameswari and Eswarapriya B. (2009). Evaluation of Diuretic activity from Tylophora indica leaves extracts. J. Pharma. Sci. Res. 1(3): 112-116.
  32. Meve, U. (1996). A new species of Tylophora (Asclepiadaceae) from west tropical Africa. Kew Bulletin (51) 3: 585-589.
  33. Mills, S. and Lee J. (2008). International market prospects for sustainably sourced medicinal and aromatic plants from India. Medicinal and Aromatic Plants from India. Plant Medicine, CIC Gargi Banerji and Sunil Pillai, Pragya.
  34. Mujeeb, M., Aeri V., Bagri P. and Khan S. (2009). Hepato protective activity of the methanolic extract of Tylophora indica (Burm. f.) Merill. Leaves. Int. J. Gr. Pharm. 3(2):125-127. Mulchandani, N.B., Iyer S.S. and Badheka L.P. (1971). Structure of tylophorinidine: a new potential antitumor alkaloid from Tylophora indica. Chem. Indus. 19: 505-506.
  35. Nayampalli, S.S. and Sheth U.K. (1979). Ind. J. Pharmacol. 11 (3): 229-232.
  36. Nayampalli, S.S., Jha A.M. and Sheth U.K. (1977). A simple model to study the effects of bronchoconstrictors and dilators and to estimate the mediators of allergy. Ind. J. Pharmacol. 9: 229-232.
  37. Patel, N.J., Gujrati V.B., Goud T., Rao N.V., Nandkumar K. and Kumar S.M. (2006). Antidiarrhoel activity of alcoholic and aqueous extracts of roots of Tylophora indica (Weigh & Arn) in rodents. Pharmacol. 1: 19-29.
  38. Patel, N.J., Gujrati V.B., Rao N.V., Gouda T.S. and Shalam M. (2008). Anti-inflammatory and antinociceptive activities of leaf extracts of Tylophora indica. Pharmacog. Mag. 4(15): 31-36.
  39. Raina, V. and Raina S. (1980). The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects. Biochem. Bioph. Res. Comm. 94(4):1074-1077.
  40. Rani, S. and J. S. Rana. (2010). In vitro propagation of Tylophora indica influence of explanting season, growth regulator synergy, culture passage and planting substrate. Am. J. Sci. 6 (12):385-392.
  41. Rastogi, R.P. and Malhotra B.N. (1999). Compendium of Indian Medicinal plants. Central Drug Research Institute, Lucknow and National Institute of Science Communication. New Delhi.1: 423-424.
  42. Ratnagiriswaran, H.N. and Venkatachalam K. (1935). The chemical examination of Tylophora asthamatica and isolation of the alkaloids tylophorine and tylophorinine. Ind. J. Med. Res. 22: 433-41.
  43. Reddy, B. K., Balaji M., Uma Reddy P., Sailaja G., Vaidyanath K. and G. Narasimha. (2009). Antifeedant and antimicrobial activity of Tylophora indica. Afr. J. Biochem. Res. 3 (12):393-397.
  44. Reddy, B.U. (2010). Enumeration of antibacterial activity of few medicinal plants by bioassay method. Eur. J. Chem. 7(4):1449-1453.
  45. Reddy, U. (2009). Antimicrobial activity of Datura stramonium L. and Tylophora indica (Burm. f.) Merr. Pharmacol. 1: 1293-1300.
  46. Sarris, J. and Flaherty J. (2002). Review of articles on medicinal herbs. Med plant update. Aus. J. Med. Herb. 14(1): 124-128.
  47. Savithramma, N. (2003). Diversity in Phanerogams of Sri Venkateswara University Of Campus Tirupati. Students offset printers, Tirupati.
  48. Saxena, H.O. and Lyoydia. (1975). Survey of the plants of Orissa. 38(4):346-351.
  49. Sharma, S., Rathi N., Kamal B., Pundir D., Kaur B. and Arya S. (2010). Conservation of diversity of highly important medicinal plants of India through tissue culture technology – a review. Agr. Biol. J. N. Am. 1(5): 827-833.
  50. Shivpuri, O.N., Singhal S.C. and Parkash D. (1977). Treatment of asthma with alcoholic extract of Tylophora indica: a crossover double blind study. Ann. Aller. 30: 407-412.
  51. Singh A.P. (2005). Promising phytochemicals from Indian medicinal plants. Ethno. Bot. Leaf. 9: 15- 23.
  52. Singh, S.P. and Verma P.N. (1984). Preliminary acute and subacute toxicity study of some homeopathic drugs. CCRH Quart. Bull. 6(14): 20-24.
  53. Sinha, S. and Mondal A. K. (2011). The morphological diversification of pollinia of some members of Asclepiadaceae. Afr. J. Biotech. 10:7981-7986.
  54. Stephen, J. and Vijayammal P.L. (2000). Anti-tumor activity of Tylophora asthmatica. Elect. J. Ind. Med. 20: 88-91.
  55. Suffness, M. and Cordella G.A. (1985). Antitumor alkaloids, pp. 14. In: Brossi, A. (Ed.), The alkaloids. Academic Press. New York.
  56. Sunanda, S., Nayampalli S.S. and Sheth U.K. (1979). Evaluation of anti-allergic activity of Tylophora indica using rat lung perfusion. Indian J. Pharmacol. 11: 229-232.
  57. The Wealth of India (1995). A Dictionary of Raw Materials and Industrial Publications and Information Directorate New Delhi, CSIR, 3, 398-401.
  58. Thomas, D.T. (2006). Effect of sugars, gibberellic acid and abscisic acid on somatic embryogenesis in Tylophora indica (Burm. f.) Merrill. Sheng Wu Gong Cheng Xue Bao 22: 465-471.
  59. Wakdikar, S. (2004). Global health care challenge: Indian experience and new prescription. Elect. J. Biotech. 3: 214-220.
  60. Wu, C.M., Yang C.W., Lee Y.Z., Chuang T.H., Wu P.L., Chao Y.S. and Lee S.J. (2009). Tylophorine arrests carcinoma cells at G1 phase by down regulating cyclin A2 expression. Biochem. Bioph. Res. Comm. 386:140-145.

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