Banner
Current IssueEditorial BoardOnline First Articles
Current IssueEditorial BoardOnline First Articles
Agricultural Reviews
Print ISSN: 0253-1496
Online ISSN: 0976-0741
NASS Rating
4.84

Chief Editor:
Pradeep K. Sharma
Sher-e-Kashmir Uni. of Agri. Sciences and Technology, J&K, INDIA
Frequency:Bi-monthly
Indexing:
AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abs...

Agricultural Reviews, volume 30 issue 4 (december 2009) : 293 - 300

BOVINE LEUKOCYTE ADHESION DEFICIENCY SYNDROME (BLAD): A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW

Vijay Kumar, Ashwani Sharma
1Dairy Cattle Breeding Division National Dairy Research Institute, Karnal-132001, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Kumar Vijay, Sharma Ashwani (2025). BOVINE LEUKOCYTE ADHESION DEFICIENCY SYNDROME (BLAD): A RECESSIVE DISORDER IN HOLSTEIN FRIESIAN CATTLE- A REVIEW. Agricultural Reviews. 30(4): 293 - 300. doi: .

ABSTRACT

The present review is to summarize findings on one of the most important recessive
hereditary disorder Bovine Leukocyte Adhesion Deficiency Syndrome (BLAD) in cattle.
It is a disease of young Holstein calves characterized by recurrent pneumonia, ulcerative
and granulomatous stomatitis, periodontitis, delayed wound healing and persistent
neutrophilia. The recessive homozygous form is lethal and since carrier animals have
viability, BLAD frequency increases by use of carrier bulls in Artificial insemination (AI).
The gene CD18 was the suspected culprit and a point mutation was eventually identified
within the alleles encoding bovine CD18 in a Holstein calf affected with BLAD. This
mutation causes aspartic acid to glycine substitution at the amino acid level. PCR-RFLP,
PCR-SSCP, AS-PCR and Tetra-primer ARMS-PCR are certain PCR based techniques which
could be used to screen BLAD in cattle. The use of these molecular technologies promises
quick detection of carriers enables their culling therefore, controlling and preventing the
spread of BLAD in the population.

REFERENCES

  1. Agerholm, J.S. et al. (1993). Acta.Vet. Scand. 34: 237-243.
  2. Anderson, D.C. et al. (1986). J. Immunol. 137: 15-27.
  3. Anderson, D.C. and Springer, T.A. (1987). Ann. Rev. Med. 38: 175-194.
  4. Andrews, A.H. et al. (1996). Br. Vet. J. 152: 347- 351.
  5. Biochard, D. et al. (1995). 46th Ann. Mett. Eur. Assoc. Anim. prod. Prague.
  6. Chung, E.R. et al. (1997). Korean J. Dairy Sci. 19: 277-288.
  7. Cox, E. et al. (1997). Vet. Immunol. Immunopathol. 58: 249-263.
  8. Czarnik, U. et al. (1997). J. App. Gen. 38: 51-55.
  9. Esmaelizad, M. et al. (2002). 7th World-Congress-on-Genetics-Applied-to-Livestock-Production, France, 1: 1-3.
  10. Fesus, L. et al. (1996). J. Anim. Breed. Gen. 116: 169-174.
  11. Garderen, E.V. et al. (1994). Vet. Quart. 16: 24-26.
  12. Giger, U. et al. (1987). J. Amer. Soc. Hematology, 69: 1622-1630.
  13. Gourreau, J.M. et al. (1998). Summa (Italy). V. 15: 61-69.
  14. Huang, Y.C. et al. (2001). J. Taiwan Livestock Res. 34: 271-278.
  15. Hynes, R.O. (1987). Cell; 48: 549- 554.
  16. Janosa, A. et al. (1999). Act. Vet. Hung. 47: 283-289.
  17. Jorgensen, A.S. et al. (1993). Acta. Vet. Scand. 34: 231-236.
  18. Kehrli, M.E. et al. (1990). Am. J. Pathol. 140: 1489-1492.
  19. Kehrli, M.E. et al. (1991). Am. J. Vet. Res. 51: 1826-1836.
  20. Kishimoto, T.K. et al. (1989). Adv. Immunol. 46: 149-182.
  21. Kriegesmann, B. et al. (1997). J. Dairy Sci. 80: 2547-2549.
  22. Kucinskiene, J. and Miceikiene, I. (2000). Latvia University of Agriculture, 162: 13-16.
  23. Kumar, (2009). Thesis, National Dairy Research Institute, Karnal, pp1- 46.
  24. Kuczaka, A. et al. (1993). Griff. Der Tierzuchter. 45: 32-35.
  25. Larson, R.S. and Springer, T.A. (1990). Immunol. Rev. 114: 181-217.
  26. Llambi, S. et al. (2003). Ars-Veterinaria, 19: 52-56.
  27. Mahdi, (2008). Thesis, National Dairy Research Institute, Karnal, pp1- 48.
  28. Meylan, M. et al. (1997). Schweiz. Arch. Tierheilkd. 139: 277-281.
  29. Mirck, M.H. et al. (1995). Cell. Mol. Bio. 41: 695-698.
  30. Mueller, K.E. et al. (1997). Vet. Immunol. Immunopathol. 58: 39-53.
  31. Muraleedharan, P. et al. (1999). Arch. Tierz., Dummerstorf, 42: 347-52.
  32. Nagahata, H. et al. (1987). J. Vet. Med. 34: 445-451.
  33. Nagahata, H. et al. (1995). Can. J. Vet. Res. 59: 1-7.
  34. Nagahata, H. et al. (1997). J. Vet. Med. Sci. 59: 233–238.
  35. Nassiry, M.R. et al. (2005). Iranian J. Biotech. 3: 125-128.
  36. Natonek, M. (2000). Biul. Inf. Inst. Zootech. 38: 29–33.
  37. Norouzy, A. et al. (2005). Russ. J. Gen. 41: 1697-1701.
  38. Orita, M. et al. (1989). Genetics, 86: 2766-2770.
  39. Patel, R.K. et al. (2003). Intas. Polivet. 4: 11-14.
  40. Patel, R.K. et al. (2007). J. App .Gen. 48: 153-155.
  41. Poli, M.A. et al. (1996). Vet. Med. 43: 163-168.
  42. Powell, R.L. et al. (1996). Dairy Sci. 79: 895-899.
  43. Ribeiro, L.A. et al. (2000). Gen. Mol. Bio. 23: 831-834.
  44. Schilcher, F. et al. (1995). Wien. Tieraerztl. Monsehr. 82: 207-212.
  45. Shu, Y. et al. (2001). Nucleic Acids Res. 29: e88
  46. Shuster, D.E. et al. (1992). Proc. Natl. Acad. Sci. U.S.A. 89: 9225-9229.
  47. Snustad, D. P. and Simmons, M.J. (1984). Exp. Med. 160: 1901-1918.
  48. 300 AGRICUTURAL REVIEWS
  49. Springer, T.A. et al. (1984). Exp. Med., 160: 1901-1918.
  50. Springer, T.A. et al. (1990). Nature (Lond.) 346: 425-434.
  51. Steinholt, H.C. et al. (1994). J. Dairy Sci., 77: 1239-1250.
  52. Sunnuck, P. et al., (2000). Mol. Ecol. 9: 1699–1710.
  53. Tainturier, D. et al. (1995). Revue-de-Medecine-Veterinaire, 146: 189-193.
  54. Tajima, M. et al. (1993). Vet. Med. Sci. 55: 145-146.
  55. Takahashi, K. et al. (1987). Jpn. 1. Vet. Sci. 49: 733-736.
  56. Tammen, I. et al. (1996). Res. Vet. Sci., 60: 218-221
Reviewed By

Download Article
In this Article
    Contact us
    Follow us

    Editorial Board

    View all (0)